Literature DB >> 25142147

IL-18: a new player in immunotherapy for age-related macular degeneration?

Matthew Campbell1, Sarah Doyle, Peter Humphries.   

Abstract

Recent evidence suggests that the pro-inflammatory cytokine IL-18 may have utility as an anti-angiogenic agent in the eye. Numerous laboratories, including our own have demonstrated the ability of murine IL-18 to prevent neovascularization in the retina, choroid and cornea in pathological scenarios. Here, we summarize the potential use of IL-18 as an immunotherapy for wet age-related macular degeneration treatment, describing past and recent findings pertaining to its biological function in the eye.

Entities:  

Keywords:  AMD; IL-18; NLRP3; VEGF; choroidal neovascularization; geographic atrophy; immunotherapy; inflammasome; retina; retinal pigment epithelium

Mesh：

Substances：

Year:  2014        PMID： 25142147     DOI： 10.1586/1744666X.2014.950231

Source DB:  PubMed          Journal:  Expert Rev Clin Immunol        ISSN： 1744-666X            Impact factor:   4.473


  8 in total

1.  Issues with the Specificity of Immunological Reagents for NLRP3: Implications for Age-related Macular Degeneration.

Authors:  Cassandra Kosmidou; Nikolaos E Efstathiou; Mien V Hoang; Shoji Notomi; Eleni K Konstantinou; Masayuki Hirano; Kosuke Takahashi; Daniel E Maidana; Pavlina Tsoka; Lucy Young; Evangelos S Gragoudas; Timothy W Olsen; Yuki Morizane; Joan W Miller; Demetrios G Vavvas
Journal:  Sci Rep       Date:  2018-01-11       Impact factor: 4.379

2.  Interleukin-33 regulates tissue remodelling and inhibits angiogenesis in the eye.

Authors:  Sofia Theodoropoulou; David A Copland; Jian Liu; Jiahui Wu; Peter J Gardner; Ema Ozaki; Sarah L Doyle; Matthew Campbell; Andrew D Dick
Journal:  J Pathol       Date:  2016-11-16       Impact factor: 7.996

3.  Association Between IL-18 and Carotid Intima-Media Thickness in Patients with Type II Diabetic Nephropathy.

Authors:  Yuanyuan Zhang; Haomiao Feng; Zhiyong Wei
Journal:  Med Sci Monit       Date:  2017-01-26

4.  Melatonin antagonizes interleukin-18-mediated inhibition on neural stem cell proliferation and differentiation.

Authors:  Zheng Li; Xingye Li; Matthew T V Chan; William Ka Kei Wu; DunXian Tan; Jianxiong Shen
Journal:  J Cell Mol Med       Date:  2017-04-21       Impact factor: 5.310

5.  Anti-VEGF Drugs Influence Epigenetic Regulation and AMD-Specific Molecular Markers in ARPE-19 Cells.

Authors:  Mohamed A Hamid; M Tarek Moustafa; Sonali Nashine; Rodrigo Donato Costa; Kevin Schneider; Shari R Atilano; Baruch D Kuppermann; M Cristina Kenney
Journal:  Cells       Date:  2021-04-12       Impact factor: 6.600

6.  Wedelolactone Attenuates N-methyl-N-nitrosourea-Induced Retinal Neurodegeneration through Suppression of the AIM2/CASP11 Pathway.

Authors:  Kevin Harkin; Josy Augustine; Alan W Stitt; Heping Xu; Mei Chen
Journal:  Biomedicines       Date:  2022-01-28

7.  Evaluation of Blood Coagulation Parameters and ADMA, NO, IL-6, and IL-18 Serum Levels in Patients with Neovascular AMD before, during, and after the Initial Loading Phase of Intravitreal Aflibercept.

Authors:  Michał Wiciński; Małgorzata Seredyka-Burduk; Sławomir Liberski; Daria Marczak; Magdalena Pol; Bartosz Malinowski; Katarzyna Pawlak-Osińska; Bartlomiej J Kaluzny
Journal:  Life (Basel)       Date:  2021-05-14

Review 8.  IL-1 Family Members Mediate Cell Death, Inflammation and Angiogenesis in Retinal Degenerative Diseases.

Authors:  Yvette Wooff; Si Ming Man; Riemke Aggio-Bruce; Riccardo Natoli; Nilisha Fernando
Journal:  Front Immunol       Date:  2019-07-16       Impact factor: 7.561
  8 in total

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