Literature DB >> 25142036

Biomarkers of sepsis and their potential value in diagnosis, prognosis and treatment.

Mary Sandquist1, Hector R Wong.   

Abstract

Biomarkers have great potential to improve the diagnosis and treatment of sepsis. The available literature supports the potential utility of sTREM-1, IL-27, suPAR, neutrophil CD64, presepsin, cfDNA and miRNAs as novel diagnostic, prognostic and treatment response biomarkers. The future of sepsis biomarkers lies in extensive validation studies of such novel biomarkers across heterogeneous populations and exploration of their power in combination. Furthermore, the use of a companion diagnostics model may augment the ability of investigators to identify novel sepsis biomarkers and develop specific therapeutic strategies based on biomarker information.

Entities:  

Keywords:  IL-27; TREM-1; biomarker; cfDNA; combination biomarkers; companion diagnostics; miRNA; neutrophil CD64; presepsin; sepsis; suPAR

Mesh：

Substances：

Year:  2014        PMID： 25142036      PMCID： PMC4654927          DOI： 10.1586/1744666X.2014.949675

Source DB:  PubMed          Journal:  Expert Rev Clin Immunol        ISSN： 1744-666X            Impact factor:   4.473


  53 in total

Review 1.  Biomarkers and surrogate endpoints: preferred definitions and conceptual framework.

Authors: 
Journal:  Clin Pharmacol Ther       Date:  2001-03       Impact factor: 6.875

Review 2.  Protein biomarker discovery and validation: the long and uncertain path to clinical utility.

Authors:  Nader Rifai; Michael A Gillette; Steven A Carr
Journal:  Nat Biotechnol       Date:  2006-08       Impact factor: 54.908

Review 3.  Neutrophil CD64 as a sepsis biomarker.

Authors:  Johannes J M L Hoffmann
Journal:  Biochem Med (Zagreb)       Date:  2011       Impact factor: 2.313

4.  Performance of interleukin-27 as a sepsis diagnostic biomarker in critically ill adults.

Authors:  Hector R Wong; Kathleen D Liu; Kirsten N Kangelaris; Patrick Lahni; Carolyn S Calfee
Journal:  J Crit Care       Date:  2014-04-18       Impact factor: 3.425

Review 5.  2001 SCCM/ESICM/ACCP/ATS/SIS International Sepsis Definitions Conference.

Authors:  Mitchell M Levy; Mitchell P Fink; John C Marshall; Edward Abraham; Derek Angus; Deborah Cook; Jonathan Cohen; Steven M Opal; Jean-Louis Vincent; Graham Ramsay
Journal:  Crit Care Med       Date:  2003-04       Impact factor: 7.598

6.  IL-27, a heterodimeric cytokine composed of EBI3 and p28 protein, induces proliferation of naive CD4+ T cells.

Authors:  Stefan Pflanz; Jackie C Timans; Jeanne Cheung; Rency Rosales; Holger Kanzler; Jonathan Gilbert; Linda Hibbert; Tatyana Churakova; Marilyn Travis; Elena Vaisberg; Wendy M Blumenschein; Jeanine D Mattson; Janet L Wagner; Wayne To; Sandra Zurawski; Terrill K McClanahan; Daniel M Gorman; J Fernando Bazan; Rene de Waal Malefyt; Donna Rennick; Robert A Kastelein
Journal:  Immunity       Date:  2002-06       Impact factor: 31.745

7.  The pediatric sepsis biomarker risk model.

Authors:  Hector R Wong; Shelia Salisbury; Qiang Xiao; Natalie Z Cvijanovich; Mark Hall; Geoffrey L Allen; Neal J Thomas; Robert J Freishtat; Nick Anas; Keith Meyer; Paul A Checchia; Richard Lin; Thomas P Shanley; Michael T Bigham; Anita Sen; Jeffrey Nowak; Michael Quasney; Jared W Henricksen; Arun Chopra; Sharon Banschbach; Eileen Beckman; Kelli Harmon; Patrick Lahni; Christopher J Lindsell
Journal:  Crit Care       Date:  2012-10-01       Impact factor: 9.097

8.  Plasma DNA concentration as a predictor of mortality and sepsis in critically ill patients.

Authors:  Andrew Rhodes; Stephen J Wort; Helen Thomas; Paul Collinson; E David Bennett
Journal:  Crit Care       Date:  2006       Impact factor: 9.097

9.  Presepsin (soluble CD14 subtype) and procalcitonin levels for mortality prediction in sepsis: data from the Albumin Italian Outcome Sepsis trial.

Authors:  Serge Masson; Pietro Caironi; Eberhard Spanuth; Ralf Thomae; Mauro Panigada; Gabriela Sangiorgi; Roberto Fumagalli; Tommaso Mauri; Stefano Isgrò; Caterina Fanizza; Marilena Romero; Gianni Tognoni; Roberto Latini; Luciano Gattinoni
Journal:  Crit Care       Date:  2014-01-07       Impact factor: 9.097

10.  The temporal version of the pediatric sepsis biomarker risk model.

Authors:  Hector R Wong; Scott L Weiss; John S Giuliano; Mark S Wainwright; Natalie Z Cvijanovich; Neal J Thomas; Geoffrey L Allen; Nick Anas; Michael T Bigham; Mark Hall; Robert J Freishtat; Anita Sen; Keith Meyer; Paul A Checchia; Thomas P Shanley; Jeffrey Nowak; Michael Quasney; Arun Chopra; Julie C Fitzgerald; Rainer Gedeit; Sharon Banschbach; Eileen Beckman; Kelli Harmon; Patrick Lahni; Christopher J Lindsell
Journal:  PLoS One       Date:  2014-03-13       Impact factor: 3.240
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  58 in total

1.  [Value of combined determination of neutrophil CD64 and procalcitonin in early diagnosis of neonatal bacterial infection].

Authors:  Dao-Jian Qin; Zong-Sheng Tang; Shu-Li Chen; Xue-Mei Xu; Shuang-Gen Mao; Shi-Fa Zhang
Journal:  Zhongguo Dang Dai Er Ke Za Zhi       Date:  2017-08

Review 2.  Sepsis: in search of cure.

Authors:  Chikkamenahalli Lakshminarayana Lakshmikanth; Shancy Petsel Jacob; Vyala Hanumanthareddy Chaithra; Hugo Caire de Castro-Faria-Neto; Gopal Kedihithlu Marathe
Journal:  Inflamm Res       Date:  2016-03-19       Impact factor: 4.575

Review 3.  Emerging infection and sepsis biomarkers: will they change current therapies?

Authors:  Lauren Jacobs; Hector R Wong
Journal:  Expert Rev Anti Infect Ther       Date:  2016-08-17       Impact factor: 5.091

Review 4.  AME evidence series 001-The Society for Translational Medicine: clinical practice guidelines for diagnosis and early identification of sepsis in the hospital.

Authors:  Zhongheng Zhang; Nathan J Smischney; Haibo Zhang; Sven Van Poucke; Panagiotis Tsirigotis; Jordi Rello; Patrick M Honore; Win Sen Kuan; Juliet June Ray; Jiancang Zhou; You Shang; Yuetian Yu; Christian Jung; Chiara Robba; Fabio Silvio Taccone; Pietro Caironi; David Grimaldi; Stefan Hofer; George Dimopoulos; Marc Leone; Sang-Bum Hong; Mabrouk Bahloul; Laurent Argaud; Won Young Kim; Herbert D Spapen; Jose Rodolfo Rocco
Journal:  J Thorac Dis       Date:  2016-09       Impact factor: 2.895

Review 5.  Individualising Therapy to Minimize Bacterial Multidrug Resistance.

Authors:  A J Heffernan; F B Sime; J Lipman; J A Roberts
Journal:  Drugs       Date:  2018-04       Impact factor: 9.546

Review 6.  Sepsis Biomarkers.

Authors:  Hector R Wong
Journal:  J Pediatr Intensive Care       Date:  2019-01-11

Review 7.  Could Biomarkers Direct Therapy for the Septic Patient?

Authors:  Clark R Sims; Trung C Nguyen; Philip R Mayeux
Journal:  J Pharmacol Exp Ther       Date:  2016-02-08       Impact factor: 4.030

8.  Association between suPAR and cardiac diastolic dysfunction among patients with preserved ejection fraction.

Authors:  Tomohiro Fujisaka; Shu-Ichi Fujita; Daichi Maeda; Kensaku Shibata; Hideaki Takahashi; Hideaki Morita; Yoshihiro Takeda; Takahide Ito; Koichi Sohmiya; Masaaki Hoshiga; Nobukazu Ishizaka
Journal:  Heart Vessels       Date:  2017-06-06       Impact factor: 2.037

Review 9.  Sepsis in Pediatric Cardiac Intensive Care.

Authors:  Derek S Wheeler; Hector R Wong
Journal:  Pediatr Crit Care Med       Date:  2016-08       Impact factor: 3.624

10.  Multi-platform 'Omics Analysis of Human Ebola Virus Disease Pathogenesis.

Authors:  Amie J Eisfeld; Peter J Halfmann; Jason P Wendler; Jennifer E Kyle; Kristin E Burnum-Johnson; Zuleyma Peralta; Tadashi Maemura; Kevin B Walters; Tokiko Watanabe; Satoshi Fukuyama; Makoto Yamashita; Jon M Jacobs; Young-Mo Kim; Cameron P Casey; Kelly G Stratton; Bobbie-Jo M Webb-Robertson; Marina A Gritsenko; Matthew E Monroe; Karl K Weitz; Anil K Shukla; Mingyuan Tian; Gabriele Neumann; Jennifer L Reed; Harm van Bakel; Thomas O Metz; Richard D Smith; Katrina M Waters; Alhaji N'jai; Foday Sahr; Yoshihiro Kawaoka
Journal:  Cell Host Microbe       Date:  2017-11-16       Impact factor: 21.023
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