Joanna E Steinglass1, Simona C Kaplan, Ying Liu, Yuanjia Wang, B Timothy Walsh. 1. Department of Psychiatry, Columbia University Medical Center, 622 West 168th Street New York, New York; Department of Psychiatry, New York State Psychiatric Institute, 1051 Riverside Drive New York, New York.
Abstract
OBJECTIVE:Anxiety is a prominent symptom in anorexia nervosa (AN), and higher pre-meal anxiety has been associated with lower caloric intake. Yet, the causal relationship has not been assessed. We proposed that reducing anxiety with a short acting benzodiazepine would increase caloric intake among individuals with AN. METHOD: In a randomized, double-blind, placebo controlled cross-over study, we administered alprazolam 0.75 mg to inpatients with AN (n = 17) and assessed caloric intake in a laboratory test meal. Within-subject differences in caloric intake, anxiety, and fatigue were compared between alprazolam and placebo days. RESULTS:Caloric intake did not differ on alprazolam versus placebo (t(15) = 1.72, p = .11). Alprazolam did not reduce anxiety, but was associated with increased fatigue. DISCUSSION: This study was not able to evaluate the causal role of anxiety in meal intake among individuals with AN, as alprazolam did not alter anxiety symptoms. These data further suggest that the therapeutic role for short-acting benzodiazepines in AN is likely limited.
RCT Entities:
OBJECTIVE:Anxiety is a prominent symptom in anorexia nervosa (AN), and higher pre-meal anxiety has been associated with lower caloric intake. Yet, the causal relationship has not been assessed. We proposed that reducing anxiety with a short acting benzodiazepine would increase caloric intake among individuals with AN. METHOD: In a randomized, double-blind, placebo controlled cross-over study, we administered alprazolam 0.75 mg to inpatients with AN (n = 17) and assessed caloric intake in a laboratory test meal. Within-subject differences in caloric intake, anxiety, and fatigue were compared between alprazolam and placebo days. RESULTS: Caloric intake did not differ on alprazolam versus placebo (t(15) = 1.72, p = .11). Alprazolam did not reduce anxiety, but was associated with increased fatigue. DISCUSSION: This study was not able to evaluate the causal role of anxiety in meal intake among individuals with AN, as alprazolam did not alter anxiety symptoms. These data further suggest that the therapeutic role for short-acting benzodiazepines in AN is likely limited.
Authors: Sahib S Khalsa; Scott E Moseman; Hung-Wen Yeh; Valerie Upshaw; Beth Persac; Eric Breese; Rachel C Lapidus; Sheridan Chappelle; Martin P Paulus; Justin S Feinstein Journal: Front Psychol Date: 2020-10-06
Authors: Sahib S Khalsa; Mahlega S Hassanpour; Michael Strober; Michelle G Craske; Armen C Arevian; Jamie D Feusner Journal: Front Psychiatry Date: 2018-09-21 Impact factor: 4.157