Literature DB >> 25139113

Effects of COMT genotype on cognitive ability and functional capacity in individuals with schizophrenia.

Elizabeth W Twamley1, Jessica P Y Hua2, Cynthia Z Burton3, Lea Vella3, Kelly Chinh2, Robert M Bilder4, John R Kelsoe5.   

Abstract

Cognitive and functional impairments are core features of schizophrenia. This study examined the catechol-O-methyltransferase (COMT) genotype and its relationship to cognition and functional capacity in 188 individuals with schizophrenia or schizoaffective disorder. We found that in a dose-response fashion, individuals with more Met alleles performed significantly better on tests of learning/memory and abstraction. The effects of COMT genotype on cognition were modest, explaining about 3% of the variance in learning/memory and abstraction. Larger studies will be needed to examine the relationships between COMT and other genes and cognitive performance and everyday functioning. Published by Elsevier B.V.

Entities:  

Keywords:  Cognition; Executive functioning; Functioning; Genetics; Learning; Memory; Psychosis

Mesh：

Substances：

Year:  2014        PMID： 25139113     DOI： 10.1016/j.schres.2014.07.041

Source DB:  PubMed          Journal:  Schizophr Res        ISSN： 0920-9964            Impact factor:   4.939


  8 in total

1.  Interaction of COMT rs4680 and BDNF rs6265 polymorphisms on functional connectivity density of the left frontal eye field in healthy young adults.

Authors:  Wei Li; Bing Liu; Jiayuan Xu; Tianzi Jiang; Chunshui Yu
Journal:  Hum Brain Mapp       Date:  2016-03-23       Impact factor: 5.038

2.  The COMT (rs165599) gene polymorphism contributes to chemotherapy-induced cognitive impairment in breast cancer patients.

Authors:  Huaidong Cheng; Wen Li; Chen Gan; Bo Zhang; Qianqian Jia; Kai Wang
Journal:  Am J Transl Res       Date:  2016-11-15       Impact factor: 4.060

3.  Personalised treatment for cognitive dysfunction in individuals with schizophrenia spectrum disorders.

Authors:  Alice Medalia; Alice M Saperstein; Marie C Hansen; Seonjoo Lee
Journal:  Neuropsychol Rehabil       Date:  2016-05-24       Impact factor: 2.868

4.  Dopaminergic Dysfunction in Mammalian Dopamine Neurons Induced by Simazine Neurotoxicity.

Authors:  Xueting Li; Jia Yu; Jianan Li; Yanping Wu; Baixiang Li
Journal:  Int J Mol Sci       Date:  2017-11-13       Impact factor: 5.923

5.  Analyzing the genes related to nicotine addiction or schizophrenia via a pathway and network based approach.

Authors:  Ying Hu; Zhonghai Fang; Yichen Yang; Dekai Rohlsen-Neal; Feng Cheng; Ju Wang
Journal:  Sci Rep       Date:  2018-02-13       Impact factor: 4.379

6.  Identification of 34 genes conferring genetic and pharmacological risk for the comorbidity of schizophrenia and smoking behaviors.

Authors:  Yunlong Ma; Jingjing Li; Yi Xu; Yan Wang; Yinghao Yao; Qiang Liu; Maiqiu Wang; Xinyi Zhao; Rongli Fan; Jiali Chen; Bin Zhang; Zhen Cai; Haijun Han; Zhongli Yang; Wenji Yuan; Yigang Zhong; Xiangning Chen; Jennie Z Ma; Thomas J Payne; Yizhou Xu; Yuping Ning; Wenyan Cui; Ming D Li
Journal:  Aging (Albany NY)       Date:  2020-02-03       Impact factor: 5.682

Review 7.  Factors Associated With Response and Resistance to Cognitive Remediation in Schizophrenia: A Critical Review.

Authors:  Stefano Barlati; Giacomo Deste; Alessandro Galluzzo; Anna Paola Perin; Paolo Valsecchi; Cesare Turrina; Antonio Vita
Journal:  Front Pharmacol       Date:  2019-01-10       Impact factor: 5.810

8.  Interaction of Catechol-O-methyltransferase Val158 Met polymorphism and sex influences association of parietal intrinsic functional connectivity and immediate verbal memory.

Authors:  Sichu Wu; Neeraj Upadhyay; Jiaming Lu; Xueyan Jiang; Shumei Li; Zhao Qing; Junxia Wang; Xue Liang; Xin Zhang; Bing Zhang
Journal:  Brain Behav       Date:  2020-08-08       Impact factor: 2.708
  8 in total

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