Literature DB >> 25138822

An assessment of the awareness of local anesthetic systemic toxicity among multi-specialty postgraduate residents.

Afrin Sagir1, Rakhee Goyal.   

Abstract

Local anesthetics (LAs) are extensively used in clinical practice by both anesthesiologists and non-anesthesiologists and are often associated with systemic toxicity. We hypothesize that this awareness is inadequate among medical specialists and entails a risk of misdiagnosis and underreporting of such events. We therefore conducted a cross-sectional questionnaire-based study to assess the level of understanding of LA use and effective management of systemic toxicity among 200 postgraduate residents of various specialties (with the exception of anesthesiology) in a tertiary care hospital in India from October to December 2013. Among those residents who had used LAs (193/200), 27 and 25 % of responders correctly identified the toxic doses of lidocaine and of lidocaine + adrenaline, respectively. Of the responders, 70 % always performed a negative aspiration of blood before injecting the drug, 27 % sometimes aspirated and the remaining 3 % never aspirated. The majority of the responders (93 %) were unaware of the toxic dose of bupivacaine. Only 70 % of responders believed that LAs could be toxic [95 % confidence interval (CI) 65.5-74.5 %], and 81 % of these correctly identified the signs and symptoms of cardiotoxicity. Only 2 % of responders knew that lipid emulsion is a part of its treatment (95 % CI 0.6-3.4 %). Based on these results, there is a definite need to increase the awareness of detection and treatment of local anesthetic toxicity among all medical practitioners who regularly use LAs.

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Year:  2014        PMID: 25138822     DOI: 10.1007/s00540-014-1904-9

Source DB:  PubMed          Journal:  J Anesth        ISSN: 0913-8668            Impact factor:   2.078


  11 in total

Review 1.  Clinical presentation of local anesthetic systemic toxicity: a review of published cases, 1979 to 2009.

Authors:  Guido Di Gregorio; Joseph M Neal; Richard W Rosenquist; Guy L Weinberg
Journal:  Reg Anesth Pain Med       Date:  2010 Mar-Apr       Impact factor: 6.288

2.  Awareness of local anaesthetic toxicity issues among hospital staff.

Authors:  J Collins
Journal:  Anaesthesia       Date:  2010-09       Impact factor: 6.955

3.  Cardiac arrest from local anesthetic toxicity after a field block and transversus abdominis plane block: a consequence of miscommunication between the anesthesiologist and surgeon.

Authors:  Vincent Scherrer; Vincent Compere; Cecile Loisel; Bertrand Dureuil
Journal:  A A Case Rep       Date:  2013-12-01

4.  Central nervous and cardiovascular effects of i.v. infusions of ropivacaine, bupivacaine and placebo in volunteers.

Authors:  K Knudsen; M Beckman Suurküla; S Blomberg; J Sjövall; N Edvardsson
Journal:  Br J Anaesth       Date:  1997-05       Impact factor: 9.166

5.  Influence of premedication on lignocaine-induced acute toxicity and plasma concentrations of lignocaine.

Authors:  J Haasio; R Hekali; P H Rosenberg
Journal:  Br J Anaesth       Date:  1988-08       Impact factor: 9.166

Review 6.  ASRA practice advisory on local anesthetic systemic toxicity.

Authors:  Joseph M Neal; Christopher M Bernards; John F Butterworth; Guido Di Gregorio; Kenneth Drasner; Michael R Hejtmanek; Michael F Mulroy; Richard W Rosenquist; Guy L Weinberg
Journal:  Reg Anesth Pain Med       Date:  2010 Mar-Apr       Impact factor: 6.288

7.  Cardiac arrest following regional anesthesia with etidocaine or bupivacaine.

Authors:  G A Albright
Journal:  Anesthesiology       Date:  1979-10       Impact factor: 7.892

8.  Lidocaine-induced altered mental status and seizure after hematoma block.

Authors:  Erik Dorf; Andrew F Kuntz; Julie Kelsey; Christopher P Holstege
Journal:  J Emerg Med       Date:  2006-10       Impact factor: 1.484

9.  Systemic toxicity from topically applied lidocaine in conjunction with fractional photothermolysis.

Authors:  Diego E Marra; Darwin Yip; Edgar F Fincher; Ronald L Moy
Journal:  Arch Dermatol       Date:  2006-08

10.  Lignocaine toxicity; a complication of local anaesthesia administered in the community.

Authors:  M J Donald; S Derbyshire
Journal:  Emerg Med J       Date:  2004-03       Impact factor: 2.740

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  2 in total

1.  Improving local anaesthetic systemic toxicity (LAST) awareness in maternity care using tailored educational tools.

Authors:  Amy E Edwards; Gemma M Bowsher; Sahil Deepak; Mohamed Ali
Journal:  BMJ Open Qual       Date:  2018-04-17

2.  Development and Preliminary Validation of LoAD Calc, a Mobile App for Calculating the Maximum Safe Single Dose of Local Anesthetics.

Authors:  Mélanie Suppan; Tal Sarah Beckmann; Cenan Gercekci; Thérèse Sigrist; Georges Louis Savoldelli; Roxane Fournier; Caroline Flora Samer
Journal:  Healthcare (Basel)       Date:  2021-06-25
  2 in total

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