Literature DB >> 25138613

Leucocyte-rich and platelet-rich fibrin for the treatment of bisphosphonate-related osteonecrosis of the jaw: a prospective feasibility study.

Jin-Woo Kim1, Sun-Jong Kim2, Myung-Rae Kim1.   

Abstract

Our aim was to assess the feasibility of using leucocyte-rich and platelet-rich fibrin (L-PRF) for the treatment of bisphosphonate-related osteonecrosis of the jaw (BRONJ) in a single group study. After treatment with L-PRF, the response of each patient was recorded 1 month and 4 months postoperatively. Further assessments were made of the site, stage, concentration of c-terminal crosslinked telopepide of type 1 collagen, and actinomycosis. Among the total of 34 patients, 26 (77%) showed complete resolution, 6 (18%) had delayed resolution, and 2 (6%) showed no resolution. There was a significant association between the response to treatment and the stage of BRONJ (p=0.002) but no other significant associations were detected. This study has shown that it is feasible to use L-PRF for the treatment of BRONJ, but the effectiveness cannot be judged with this study design. Randomised prospective trials are needed to confirm this.
Copyright © 2014 The British Association of Oral and Maxillofacial Surgeons. Published by Elsevier Ltd. All rights reserved.

Entities:  

Keywords:  Bisphosphonate; Growth factor; Osteonecrosis of the jaw; Platelet concentrate; Platelet-rich fibrin

Mesh：

Substances：

Year:  2014        PMID： 25138613     DOI： 10.1016/j.bjoms.2014.07.256

Source DB:  PubMed          Journal:  Br J Oral Maxillofac Surg        ISSN： 0266-4356            Impact factor:   1.651


  20 in total

1.  Platelet-rich fibrin may reduce the risk of delayed recovery in tooth-extracted patients undergoing oral bisphosphonate therapy: a trial study.

Authors:  Takuya Asaka; Noritaka Ohga; Yutaka Yamazaki; Jun Sato; Chiharu Satoh; Yoshimasa Kitagawa
Journal:  Clin Oral Investig       Date:  2016-11-11       Impact factor: 3.573

2.  Efficacy of fibrin-rich platelets and leukocytes (L-PRF) in tissue repair in surgical oral procedures in patients using zoledronic acid-case-control study.

Authors:  Guilherme Klein Parise; Brenda Nazareth Costa; Miriã Lima Nogueira; Laurindo Moacir Sassi; Juliana Lucena Schussel
Journal:  Oral Maxillofac Surg       Date:  2022-06-24

3.  Stage-specific therapeutic strategies of medication-related osteonecrosis of the jaws: a systematic review and meta-analysis of the drug suspension protocol.

Authors:  Luca Ramaglia; Agostino Guida; Vincenzo Iorio-Siciliano; Alessandro Cuozzo; Andrea Blasi; Anton Sculean
Journal:  Clin Oral Investig       Date:  2018-01-13       Impact factor: 3.573

Review 4.  [Research progress on platelet-rich fibrin derivatives].

Authors:  Yao-Ren Chang; Chun Liu; Li-Hua Yin
Journal:  Hua Xi Kou Qiang Yi Xue Za Zhi       Date:  2019-12-01

Review 5.  Medication-Related Osteonecrosis of the Jaw: New Insights into Molecular Mechanisms and Cellular Therapeutic Approaches.

Authors:  Thomas Lombard; Virginie Neirinckx; Bernard Rogister; Yves Gilon; Sabine Wislet
Journal:  Stem Cells Int       Date:  2016-09-18       Impact factor: 5.443

Review 6.  Treatment of osteonecrosis of the jaw related to bisphosphonates and other antiresorptive agents.

Authors:  F-J Rodriguez-Lozano; R-E Oñate-Sánchez
Journal:  Med Oral Patol Oral Cir Bucal       Date:  2016-09-01

Review 7.  The role of Leucocyte-rich and platelet-rich fibrin (L-PRF) in the treatment of the medication-related osteonecrosis of the jaws (MRONJ).

Authors:  Jorge A Cano-Durán; Juan-Francisco Peña-Cardelles; Daniel Ortega-Concepción; Víctor M Paredes-Rodríguez; Mariano García-Riart; Juan López-Quiles
Journal:  J Clin Exp Dent       Date:  2017-08-01

8.  Conservative Surgical Treatment of Bisphosphonate-Related Osteonecrosis of the Jaw with Er,Cr:YSGG Laser and Platelet-Rich Plasma: A Longitudinal Study.

Authors:  Rodolfo Mauceri; Vera Panzarella; Laura Maniscalco; Alberto Bedogni; Maria Ester Licata; Antonino Albanese; Francesca Toia; Enzo Maria Giuseppe Cumbo; Giuseppina Mazzola; Olga Di Fede; Giuseppina Campisi
Journal:  Biomed Res Int       Date:  2018-08-19       Impact factor: 3.411

Review 9.  Dental Implant Placement in Patients on Bisphosphonate Therapy: a Systematic Review.

Authors:  Rokas Gelazius; Lukas Poskevicius; Dalius Sakavicius; Vaidas Grimuta; Gintaras Juodzbalys
Journal:  J Oral Maxillofac Res       Date:  2018-09-30

Review 10.  Medication-related Osteonecrosis of the Jaw: A Review.

Authors:  Nouf A AlDhalaan; Asma BaQais; Ahmad Al-Omar
Journal:  Cureus       Date:  2020-02-10
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