BACKGROUND: Diabetes mellitus (DM) is a well-recognized risk factor for heart failure (HF). We hypothesized that HF also increases the risk for DM. OBJECTIVE: We explored the hypothesis that HF is a risk factor for DM. METHODS: The Cardiovascular Health Study was a prospective cohort study of cardiovascular risk in ambulatory older adults. We used a limited-access dataset provided by the National Heart, Lung and Blood Institute. The impact of HF at baseline on DM after 3 or 4 years was examined in a cohort of 3,748 nondiabetic participants aged ≥65 years. The magnitude and significance of the association were evaluated using logistic regression models. Analyses were performed with and without adjustment for confounders and separately among subjects with normal and impaired fasting glucose at baseline. RESULTS: Among subjects with normal fasting glucose at baseline, HF significantly increased the odds of developing impaired fasting glucose after 3 or 4 years [odds ratio (OR) 2.18, 95% confidence interval (CI) 1.03-4.61, p = 0.043] or overt DM (OR 4.78, 95% CI 1.84-12.4, p < 0.001). After adjusting for demographic and biomedical factors, HF remained significantly associated with a worsening DM status (OR 2.43, 95% CI 1.38-4.29, p = 0.002). CONCLUSIONS: In the elderly population, the presence of HF more than doubles the incidence of DM within a few years. This association remains significant when adjusting for age, gender and cardiovascular comorbidities.
BACKGROUND:Diabetes mellitus (DM) is a well-recognized risk factor for heart failure (HF). We hypothesized that HF also increases the risk for DM. OBJECTIVE: We explored the hypothesis that HF is a risk factor for DM. METHODS: The Cardiovascular Health Study was a prospective cohort study of cardiovascular risk in ambulatory older adults. We used a limited-access dataset provided by the National Heart, Lung and Blood Institute. The impact of HF at baseline on DM after 3 or 4 years was examined in a cohort of 3,748 nondiabetic participants aged ≥65 years. The magnitude and significance of the association were evaluated using logistic regression models. Analyses were performed with and without adjustment for confounders and separately among subjects with normal and impaired fasting glucose at baseline. RESULTS: Among subjects with normal fasting glucose at baseline, HF significantly increased the odds of developing impaired fasting glucose after 3 or 4 years [odds ratio (OR) 2.18, 95% confidence interval (CI) 1.03-4.61, p = 0.043] or overt DM (OR 4.78, 95% CI 1.84-12.4, p < 0.001). After adjusting for demographic and biomedical factors, HF remained significantly associated with a worsening DM status (OR 2.43, 95% CI 1.38-4.29, p = 0.002). CONCLUSIONS: In the elderly population, the presence of HF more than doubles the incidence of DM within a few years. This association remains significant when adjusting for age, gender and cardiovascular comorbidities.
Authors: Celestin Missikpode; Ramon A Durazo-Arvizu; Richard S Cooper; Matthew James OʼBrien; Sheila F Castaneda; Gregory A Talavera; Linda C Gallo; Maria M Llabre; Marisa J Perera; Krista M Perreira; Ana C Ricardo; Amber Pirzada; James P Lash; Martha Daviglus Journal: J Diabetes Date: 2021-10-11 Impact factor: 4.530
Authors: Tran Kim Son; Ngo Hoang Toan; Nguyen Thang; Huynh Le Trong Tuong; Hoang Anh Tien; Nguyen Hai Thuy; Huynh Van Minh; Paul Valensi Journal: Cardiovasc Diabetol Date: 2022-05-14 Impact factor: 8.949
Authors: Luis E Echeverría; Lyda Z Rojas; Luis A López; Oscar L Rueda-Ochoa; Sergio Alejandro Gómez-Ochoa; Carlos A Morillo Journal: Glob Heart Date: 2020-04-24