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Literature DB >> 2513807

Adipocyte plasma-membrane Gi and Gs in insulinopenic diabetic patients.

J J Ohisalo¹, H L Vikman, S Ranta, M D Houslay, G Milligan.

Abstract

Changes in the amounts and functions of G-proteins have been reported in diabetic rats. We determined the Gi/Gs ratio of adipocyte plasma membranes in six insulinopenic diabetic patients and matched controls by immunoblotting with antisera against synthetic peptides corresponding to regions of G-proteins. No consistent changes in the Gi/Gs ratio were observed. It is still possible that the functional status of the G-proteins may be altered in diabetes.

Entities: Disease Species

Mesh：

Substances：

Year: 1989 PMID： 2513807 PMCID： PMC1133575 DOI： 10.1042/bj2640289

Source DB: PubMed Journal: Biochem J ISSN： 0264-6021 Impact factor: 3.857

15 in total

1. METABOLISM OF ISOLATED FAT CELLS. I. EFFECTS OF HORMONES ON GLUCOSE METABOLISM AND LIPOLYSIS.

Authors: M RODBELL
Journal: J Biol Chem Date: 1964-02 Impact factor: 5.157

2. G proteins and diabetes.

Authors: S R Pennington
Journal: Nature Date: 1987 May 21-27 Impact factor: 49.962

Review 3. Techniques used in the identification and analysis of function of pertussis toxin-sensitive guanine nucleotide binding proteins.

Authors: G Milligan
Journal: Biochem J Date: 1988-10-01 Impact factor: 3.857

4. Pertussis toxin effects on adenylate cyclase activity, cyclic AMP accumulation and lipolysis in adipocytes from hypothyroid, euthyroid and hyperthyroid rats.

Authors: I Mills; J A García-Sainz; J N Fain
Journal: Biochim Biophys Acta Date: 1986-05-21

5. Treatment of intact hepatocytes with either the phorbol ester TPA or glucagon elicits the phosphorylation and functional inactivation of the inhibitory guanine nucleotide regulatory protein Gi.

Authors: N J Pyne; G J Murphy; G Milligan; M D Houslay
Journal: FEBS Lett Date: 1989-01-16 Impact factor: 4.124

Review 6. The biochemistry of diabetes.

Authors: R Taylor; L Agius
Journal: Biochem J Date: 1988-03-15 Impact factor: 3.857

10. Chemically induced hypothyroidism produces elevated amounts of the alpha subunit of the inhibitory guanine nucleotide binding protein (Gi) and the beta subunit common to all G-proteins.

Authors: G Milligan; A M Spiegel; C G Unson; E D Saggerson
Journal: Biochem J Date: 1987-10-01 Impact factor: 3.857

3 in total

Adipocyte plasma-membrane Gi and Gs in insulinopenic diabetic patients.

1. METABOLISM OF ISOLATED FAT CELLS. I. EFFECTS OF HORMONES ON GLUCOSE METABOLISM AND LIPOLYSIS.

2. G proteins and diabetes.

Review 3. Techniques used in the identification and analysis of function of pertussis toxin-sensitive guanine nucleotide binding proteins.

4. Pertussis toxin effects on adenylate cyclase activity, cyclic AMP accumulation and lipolysis in adipocytes from hypothyroid, euthyroid and hyperthyroid rats.

5. Treatment of intact hepatocytes with either the phorbol ester TPA or glucagon elicits the phosphorylation and functional inactivation of the inhibitory guanine nucleotide regulatory protein Gi.

Review 6. The biochemistry of diabetes.

7. Thyroid status and adenosine content of adipose tissue.

8. Abolition of the expression of inhibitory guanine nucleotide regulatory protein Gi activity in diabetes.

9. Adenosine, thyroid status and regulation of lipolysis.

10. Chemically induced hypothyroidism produces elevated amounts of the alpha subunit of the inhibitory guanine nucleotide binding protein (Gi) and the beta subunit common to all G-proteins.

1. Untreated type 1 diabetes does not impair adenosine-mediated inhibition of lipolysis in human adipocytes.

2. Selective beta1-adrenoceptor blockade enhances the activity of the stimulatory G-protein in human atrial myocardium.

3. The inhibitory guanine nucleotide-binding protein Gi2alpha induces and potentiates adipocyte differentiation.