Adriana Moleres1, Fermín I Milagro2, Ascensión Marcos3, Eduardo González Zorzano4, Cristina Campoy5, Jesús M Garagorri6, M Cristina Azcona-Sanjulian7, J Alfredo Martínez8, Amelia Marti9. 1. Department of Nutrition. Food Science. Physiology and Toxicology. University of Navarra. Pamplona. Spain.. amoleres@alumni.unav.es. 2. Department of Nutrition. Food Science. Physiology and Toxicology. University of Navarra. Pamplona. Spain. CIBERobn. Physiopathology of Obesity and Nutrition. Institute of Health Carlos III. Madrid. Spain.. fmilagro@unav.es. 3. Immunonutrition Research Group. Department of Metabolism and Nutrition. Institute of Food Science. Technology and Nutrition (ICTAN). Instituto del Frío. Spanish National Research Council (CSIC). Madrid. Spain.. amarcos@if.csic.es. 4. Medical Department. Cinfa Laboratoies. Pamplona. España.. eduardo.gonzalez@cinfa.com. 5. Pediatric Department. Medicine School. Universidad de Granada. Granada. Spain.. ccampoy@ugr.es. 6. Department of Paediatrics. Radiology and Physical Medicine. Universidad de Zaragoza. Spain.. jesus_maria@garagorri.e.telefonica.net. 7. Paediatric Endocrinology Unit. Department of Pediatrics. University of Navarra Hospital. Pamplona. Spain.. cazcona@unav.es. 8. Department of Nutrition. Food Science. Physiology and Toxicology. University of Navarra. Pamplona. Spain. CIBERobn. Physiopathology of Obesity and Nutrition. Institute of Health Carlos III. Madrid. Spain.. jalfmtz@unav.es. 9. Department of Nutrition. Food Science. Physiology and Toxicology. University of Navarra. Pamplona. Spain. CIBERobn. Physiopathology of Obesity and Nutrition. Institute of Health Carlos III. Madrid. Spain.. amarti@unav.es.
Abstract
BACKGROUND: Some SNPs related to lipid and energy metabolism may be implicated not only in the development of obesity and associated comorbidities, but also in the weight loss response after a nutritional intervention. OBJECTIVE: In this context, the present study analyzed four SNPs located within four genes known to be associated with obesity and other obesity-related complications, and their putative role in a weight-loss intervention in overweight/obese adolescents. METHODS: The study population consisted of 199 overweight/obese adolescents (13-16 yr old) undergoing 10 weeks of a weight loss multidisciplinary intervention: the EVASYON programme (www.estudioevasyon.org). Adolescents were genotyped for 4 SNPs, and anthropometric measurements and biochemical markers were analyzed at the beginning and after the intervention. RESULTS: Interestingly, APOA5(rs662799) was associated with the baseline anthropometric and biochemical outcomes, whereas FTO (rs9939609) seemed to be related with the change of these values after the 10-week intervention. The other two SNPs, located in the CETP (rs1800777) and the APOA1 (rs670) genes, showed important relationships with adiposity markers. Specifically, a combined model including both SNPs turned up to explain up to 24% of BMI-SDS change after 10 weeks of the multidisciplinary intervention, which may contribute to under - stand the weight loss response. CONCLUSION: Common variants in genes related to lipid and energy metabolism may influence not only biochemical outcomes but also weight loss response after a multidisciplinary intervention carried out in obese/overweight adolescents.. Copyright AULA MEDICA EDICIONES 2014. Published by AULA MEDICA. All rights reserved.
BACKGROUND: Some SNPs related to lipid and energy metabolism may be implicated not only in the development of obesity and associated comorbidities, but also in the weight loss response after a nutritional intervention. OBJECTIVE: In this context, the present study analyzed four SNPs located within four genes known to be associated with obesity and other obesity-related complications, and their putative role in a weight-loss intervention in overweight/obese adolescents. METHODS: The study population consisted of 199 overweight/obese adolescents (13-16 yr old) undergoing 10 weeks of a weight loss multidisciplinary intervention: the EVASYON programme (www.estudioevasyon.org). Adolescents were genotyped for 4 SNPs, and anthropometric measurements and biochemical markers were analyzed at the beginning and after the intervention. RESULTS: Interestingly, APOA5(rs662799) was associated with the baseline anthropometric and biochemical outcomes, whereas FTO (rs9939609) seemed to be related with the change of these values after the 10-week intervention. The other two SNPs, located in the CETP (rs1800777) and the APOA1 (rs670) genes, showed important relationships with adiposity markers. Specifically, a combined model including both SNPs turned up to explain up to 24% of BMI-SDS change after 10 weeks of the multidisciplinary intervention, which may contribute to under - stand the weight loss response. CONCLUSION: Common variants in genes related to lipid and energy metabolism may influence not only biochemical outcomes but also weight loss response after a multidisciplinary intervention carried out in obese/overweight adolescents.. Copyright AULA MEDICA EDICIONES 2014. Published by AULA MEDICA. All rights reserved.
Authors: Omar Ramos-Lopez; Jose I Riezu-Boj; Fermin I Milagro; Marta Cuervo; Leticia Goni; J A Martinez Journal: Int J Genomics Date: 2018-11-19 Impact factor: 2.326
Authors: Alisa Weiland; Lena Kasemann Nannette; Stephan Zipfel; Stefan Ehehalt; Katrin Ziser; Florian Junne; Isabelle Mack Journal: Front Public Health Date: 2022-03-25