| Literature DB >> 25136012 |
Kady Phe1, Michael L Johnson2, Hannah R Palmer3, Vincent H Tam4.
Abstract
Despite concerns about its nephrotoxicity, colistin often remains the only effective agent for treating multidrug-resistant Gram-negative infections. Published studies have reported a wide range of nephrotoxicity risk factors. To assess the clinical utility of various models, we compared their performances for predicting the risk of nephrotoxicity. We identified a model demonstrating reasonable overall risk assessment, with an observed/expected ratio of 1.29 (95% confidence interval [CI], 0.68 to 1.90) and a positive predictive value of 87.5% for identifying patients at high risk of developing nephrotoxicity.Entities:
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Year: 2014 PMID: 25136012 PMCID: PMC4249357 DOI: 10.1128/AAC.03776-14
Source DB: PubMed Journal: Antimicrob Agents Chemother ISSN: 0066-4804 Impact factor: 5.191