Matthew R Lammi1, Nathaniel Marchetti2, Gerard J Criner2. 1. Louisiana State University Health Sciences Center, New Orleans, LA, United States. Electronic address: mlammi@lsuhsc.edu. 2. Temple University School of Medicine, Philadelphia, PA, United States.
Abstract
INTRODUCTION: Dynamic hyperinflation (DH) after lung volume reduction surgery (LVRS) has not been well studied. It is not known if reductions in DH correlate with improvements in exercise performance post-LVRS. METHODS: Forty-two upper-lobe predominant emphysema patients who underwent LVRS were analyzed. Inspiratory capacity was measured every 2 min during symptom-limited cardiopulmonary exercise test (CPET) and end-expiratory lung volumes (EELV) were calculated. The main measure of DH was EELV/TLC ratio matched at metabolic isotimes (based on the post-rehabilitation VCO2max). RESULTS: Patients had very severe airflow obstruction (FEV1 28.3 ± 7.0% predicted), were hyperinflated (TLC 125 ± 17% predicted) and gas trapped (RV 198 ± 39% predicted). Compared to the post-rehab baseline, dynamic hyperinflation (EELV/TLC) was significantly reduced after LVRS at 6, 12, 24, and 36 months. There were also increases in inspiratory reserve volume at matched isotimes after surgery. Patients adopted a slower, deeper breathing pattern during exercise after LVRS, which strongly correlated to reductions in DH. There were significant correlations between reductions in DH (EELV/TLC @50% VCO2max) and improvements in 6 min walk distance (Pearson r = -0.411, p = 0.02, n = 33) and maximal watts on CPET (Spearman r = -0.536, p = 0.001, n = 33) when comparing post-rehabilitation and 6 month post-LVRS values. CONCLUSION: Dynamic hyperinflation during exercise was reduced after LVRS (up to 3 years) and there was a strong association between alterations in breathing pattern and reduced DH after LVRS. This is the first study to demonstrate that reductions in DH correlated with improved exercise performance following LVRS.
INTRODUCTION: Dynamic hyperinflation (DH) after lung volume reduction surgery (LVRS) has not been well studied. It is not known if reductions in DH correlate with improvements in exercise performance post-LVRS. METHODS: Forty-two upper-lobe predominant emphysemapatients who underwent LVRS were analyzed. Inspiratory capacity was measured every 2 min during symptom-limited cardiopulmonary exercise test (CPET) and end-expiratory lung volumes (EELV) were calculated. The main measure of DH was EELV/TLC ratio matched at metabolic isotimes (based on the post-rehabilitation VCO2max). RESULTS:Patients had very severe airflow obstruction (FEV1 28.3 ± 7.0% predicted), were hyperinflated (TLC 125 ± 17% predicted) and gas trapped (RV 198 ± 39% predicted). Compared to the post-rehab baseline, dynamic hyperinflation (EELV/TLC) was significantly reduced after LVRS at 6, 12, 24, and 36 months. There were also increases in inspiratory reserve volume at matched isotimes after surgery. Patients adopted a slower, deeper breathing pattern during exercise after LVRS, which strongly correlated to reductions in DH. There were significant correlations between reductions in DH (EELV/TLC @50% VCO2max) and improvements in 6 min walk distance (Pearson r = -0.411, p = 0.02, n = 33) and maximal watts on CPET (Spearman r = -0.536, p = 0.001, n = 33) when comparing post-rehabilitation and 6 month post-LVRS values. CONCLUSION: Dynamic hyperinflation during exercise was reduced after LVRS (up to 3 years) and there was a strong association between alterations in breathing pattern and reduced DH after LVRS. This is the first study to demonstrate that reductions in DH correlated with improved exercise performance following LVRS.
Authors: T E Dolmage; T K Waddell; F Maltais; G H Guyatt; T R J Todd; S Keshavjee; S van Rooy; B Krip; P LeBlanc; R S Goldstein Journal: Eur Respir J Date: 2004-02 Impact factor: 16.671
Authors: Alfred Fishman; Fernando Martinez; Keith Naunheim; Steven Piantadosi; Robert Wise; Andrew Ries; Gail Weinmann; Douglas E Wood Journal: N Engl J Med Date: 2003-05-20 Impact factor: 91.245
Authors: Matthew R Lammi; Mohamed A Ghonim; Jessica Johnson; Johnny D'Aquin; John B Zamjahn; Andy Pellett; Samuel C Okpechi; Connie Romaine; Kusma Pyakurel; Hahn H Luu; Judd E Shellito; A Hamid Boulares; Bennett P deBoisblanc Journal: Respir Med Date: 2021-03-08 Impact factor: 3.415