Literature DB >> 25135348

Genetic variation at glucose and insulin trait loci and response to glucose-insulin-potassium (GIK) therapy: the IMMEDIATE trial.

K L Ellis1, Y Zhou2, J R Beshansky3, E Ainehsazan1, Y Yang1, H P Selker3, G S Huggins4, L A Cupples2, I Peter1.   

Abstract

The mechanistic effects of intravenous glucose, insulin and potassium (GIK) in cardiac ischemia are not well understood. We conducted a genetic sub-study of the Immediate Myocardial Metabolic Enhancement During Initial Assessment and Treatment in Emergency care (IMMEDIATE) Trial to explore effects of common and rare glucose and insulin-related genetic loci on initial to 6-h and 6- to 12-h change in plasma glucose and potassium. We identified 27 NOTCH2/ADAM30 and 8 C2CD4B variants conferring a 40-57% increase in glucose during the first 6 h of infusion (P<5.96 × 10(-6)). Significant associations were also found for ABCB11 and SLC30A8 single-nucleotide polymorphisms (SNPs) and glucose responses, and an SEC61A2 SNP with a potassium response to GIK. These studies identify genetic factors that may impact the metabolic response to GIK, which could influence treatment benefits in the setting of acute coronary syndromes (ACS).

Entities:  

Mesh：

Substances：

Year:  2014        PMID： 25135348      PMCID： PMC6512969          DOI： 10.1038/tpj.2014.41

Source DB:  PubMed          Journal:  Pharmacogenomics J        ISSN： 1470-269X            Impact factor:   3.550


  29 in total

1.  A genome-wide association study in the Japanese population identifies susceptibility loci for type 2 diabetes at UBE2E2 and C2CD4A-C2CD4B.

Authors:  Toshimasa Yamauchi; Kazuo Hara; Shiro Maeda; Kazuki Yasuda; Atsushi Takahashi; Momoko Horikoshi; Masahiro Nakamura; Hayato Fujita; Niels Grarup; Stephane Cauchi; Daniel P K Ng; Ronald C W Ma; Tatsuhiko Tsunoda; Michiaki Kubo; Hirotaka Watada; Hiroshi Maegawa; Miki Okada-Iwabu; Masato Iwabu; Nobuhiro Shojima; Hyoung Doo Shin; Gitte Andersen; Daniel R Witte; Torben Jørgensen; Torsten Lauritzen; Annelli Sandbæk; Torben Hansen; Toshihiko Ohshige; Shintaro Omori; Ikuo Saito; Kohei Kaku; Hiroshi Hirose; Wing-Yee So; Delphine Beury; Juliana C N Chan; Kyong Soo Park; E Shyong Tai; Chikako Ito; Yasushi Tanaka; Atsunori Kashiwagi; Ryuzo Kawamori; Masato Kasuga; Philippe Froguel; Oluf Pedersen; Naoyuki Kamatani; Yusuke Nakamura; Takashi Kadowaki
Journal:  Nat Genet       Date:  2010-09-05       Impact factor: 38.330

2.  Adjusting multiple testing in multilocus analyses using the eigenvalues of a correlation matrix.

Authors:  J Li; L Ji
Journal:  Heredity (Edinb)       Date:  2005-09       Impact factor: 3.821

3.  Principal components analysis corrects for stratification in genome-wide association studies.

Authors:  Alkes L Price; Nick J Patterson; Robert M Plenge; Michael E Weinblatt; Nancy A Shadick; David Reich
Journal:  Nat Genet       Date:  2006-07-23       Impact factor: 38.330

Review 4.  Glucose-insulin-potassium revived: current status in acute coronary syndromes and the energy-depleted heart.

Authors:  Alexandra N Grossman; Lionel H Opie; Joni R Beshansky; Joanne S Ingwall; Charles E Rackley; Harry P Selker
Journal:  Circulation       Date:  2013-03-05       Impact factor: 29.690

5.  Out-of-hospital administration of intravenous glucose-insulin-potassium in patients with suspected acute coronary syndromes: the IMMEDIATE randomized controlled trial.

Authors:  Harry P Selker; Joni R Beshansky; Patricia R Sheehan; Joseph M Massaro; John L Griffith; Ralph B D'Agostino; Robin Ruthazer; James M Atkins; Assaad J Sayah; Michael K Levy; Michael E Richards; Tom P Aufderheide; Darren A Braude; Ronald G Pirrallo; Delanor D Doyle; Ralph J Frascone; Donald J Kosiak; James M Leaming; Carin M Van Gelder; Gert-Paul Walter; Marvin A Wayne; Robert H Woolard; Lionel H Opie; Charles E Rackley; Carl S Apstein; James E Udelson
Journal:  JAMA       Date:  2012-03-27       Impact factor: 56.272

6.  Clinical risk factors, DNA variants, and the development of type 2 diabetes.

Authors:  Valeriya Lyssenko; Anna Jonsson; Peter Almgren; Nicoló Pulizzi; Bo Isomaa; Tiinamaija Tuomi; Göran Berglund; David Altshuler; Peter Nilsson; Leif Groop
Journal:  N Engl J Med       Date:  2008-11-20       Impact factor: 91.245

7.  Reorientation of the first signal-anchor sequence during potassium channel biogenesis at the Sec61 complex.

Authors:  Helen R Watson; Lydia Wunderley; Tereza Andreou; Jim Warwicker; Stephen High
Journal:  Biochem J       Date:  2013-12-01       Impact factor: 3.857

8.  The metabochip, a custom genotyping array for genetic studies of metabolic, cardiovascular, and anthropometric traits.

Authors:  Benjamin F Voight; Hyun Min Kang; Jun Ding; Cameron D Palmer; Carlo Sidore; Peter S Chines; Noël P Burtt; Christian Fuchsberger; Yanming Li; Jeanette Erdmann; Timothy M Frayling; Iris M Heid; Anne U Jackson; Toby Johnson; Tuomas O Kilpeläinen; Cecilia M Lindgren; Andrew P Morris; Inga Prokopenko; Joshua C Randall; Richa Saxena; Nicole Soranzo; Elizabeth K Speliotes; Tanya M Teslovich; Eleanor Wheeler; Jared Maguire; Melissa Parkin; Simon Potter; N William Rayner; Neil Robertson; Kathleen Stirrups; Wendy Winckler; Serena Sanna; Antonella Mulas; Ramaiah Nagaraja; Francesco Cucca; Inês Barroso; Panos Deloukas; Ruth J F Loos; Sekar Kathiresan; Patricia B Munroe; Christopher Newton-Cheh; Arne Pfeufer; Nilesh J Samani; Heribert Schunkert; Joel N Hirschhorn; David Altshuler; Mark I McCarthy; Gonçalo R Abecasis; Michael Boehnke
Journal:  PLoS Genet       Date:  2012-08-02       Impact factor: 5.917

9.  Association testing of novel type 2 diabetes risk alleles in the JAZF1, CDC123/CAMK1D, TSPAN8, THADA, ADAMTS9, and NOTCH2 loci with insulin release, insulin sensitivity, and obesity in a population-based sample of 4,516 glucose-tolerant middle-aged Danes.

Authors:  Niels Grarup; Gitte Andersen; Nikolaj T Krarup; Anders Albrechtsen; Ole Schmitz; Torben Jørgensen; Knut Borch-Johnsen; Torben Hansen; Oluf Pedersen
Journal:  Diabetes       Date:  2008-06-20       Impact factor: 9.461

10.  Variants in MTNR1B influence fasting glucose levels.

Authors:  Inga Prokopenko; Claudia Langenberg; Jose C Florez; Richa Saxena; Nicole Soranzo; Gudmar Thorleifsson; Ruth J F Loos; Alisa K Manning; Anne U Jackson; Yurii Aulchenko; Simon C Potter; Michael R Erdos; Serena Sanna; Jouke-Jan Hottenga; Eleanor Wheeler; Marika Kaakinen; Valeriya Lyssenko; Wei-Min Chen; Kourosh Ahmadi; Jacques S Beckmann; Richard N Bergman; Murielle Bochud; Lori L Bonnycastle; Thomas A Buchanan; Antonio Cao; Alessandra Cervino; Lachlan Coin; Francis S Collins; Laura Crisponi; Eco J C de Geus; Abbas Dehghan; Panos Deloukas; Alex S F Doney; Paul Elliott; Nelson Freimer; Vesela Gateva; Christian Herder; Albert Hofman; Thomas E Hughes; Sarah Hunt; Thomas Illig; Michael Inouye; Bo Isomaa; Toby Johnson; Augustine Kong; Maria Krestyaninova; Johanna Kuusisto; Markku Laakso; Noha Lim; Ulf Lindblad; Cecilia M Lindgren; Owen T McCann; Karen L Mohlke; Andrew D Morris; Silvia Naitza; Marco Orrù; Colin N A Palmer; Anneli Pouta; Joshua Randall; Wolfgang Rathmann; Jouko Saramies; Paul Scheet; Laura J Scott; Angelo Scuteri; Stephen Sharp; Eric Sijbrands; Jan H Smit; Kijoung Song; Valgerdur Steinthorsdottir; Heather M Stringham; Tiinamaija Tuomi; Jaakko Tuomilehto; André G Uitterlinden; Benjamin F Voight; Dawn Waterworth; H-Erich Wichmann; Gonneke Willemsen; Jacqueline C M Witteman; Xin Yuan; Jing Hua Zhao; Eleftheria Zeggini; David Schlessinger; Manjinder Sandhu; Dorret I Boomsma; Manuela Uda; Tim D Spector; Brenda Wjh Penninx; David Altshuler; Peter Vollenweider; Marjo Riitta Jarvelin; Edward Lakatta; Gerard Waeber; Caroline S Fox; Leena Peltonen; Leif C Groop; Vincent Mooser; L Adrienne Cupples; Unnur Thorsteinsdottir; Michael Boehnke; Inês Barroso; Cornelia Van Duijn; Josée Dupuis; Richard M Watanabe; Kari Stefansson; Mark I McCarthy; Nicholas J Wareham; James B Meigs; Gonçalo R Abecasis
Journal:  Nat Genet       Date:  2008-12-07       Impact factor: 38.330
View more
  5 in total

1.  Genetic modifiers of response to glucose-insulin-potassium (GIK) infusion in acute coronary syndromes and associations with clinical outcomes in the IMMEDIATE trial.

Authors:  K L Ellis; Y Zhou; J R Beshansky; E Ainehsazan; H P Selker; L A Cupples; G S Huggins; I Peter
Journal:  Pharmacogenomics J       Date:  2015-03-17       Impact factor: 3.550

2.  Common variants associated with changes in levels of circulating free fatty acids after administration of glucose-insulin-potassium (GIK) therapy in the IMMEDIATE trial.

Authors:  K L Ellis; Y Zhou; L Rodriguez-Murillo; J R Beshansky; E Ainehsazan; H P Selker; G S Huggins; L A Cupples; I Peter
Journal:  Pharmacogenomics J       Date:  2015-12-08       Impact factor: 3.550

3.  Glucose-Insulin-Potassium Alleviates Intestinal Mucosal Barrier Injuries Involving Decreased Expression of Uncoupling Protein 2 and NLR Family-Pyrin Domain-Containing 3 Inflammasome in Polymicrobial Sepsis.

Authors:  Jun-Liang Zhang; Yi-Ting Chen; Guang-Dao Chen; Tao Wang; Ju-Xin Zhang; Qi-Yi Zeng
Journal:  Biomed Res Int       Date:  2017-03-27       Impact factor: 3.411

4.  Liver Expression of IGF2 and Related Proteins in ZBED6 Gene-Edited Pig by RNA-Seq.

Authors:  Haidong Zhao; Mingli Wu; Shirong Liu; Xiaoqin Tang; Xiaohua Yi; Qi Li; Shuhui Wang; Xiuzhu Sun
Journal:  Animals (Basel)       Date:  2020-11-22       Impact factor: 2.752

5.  ADAM30 Downregulates APP-Linked Defects Through Cathepsin D Activation in Alzheimer's Disease.

Authors:  Florent Letronne; Geoffroy Laumet; Anne-Marie Ayral; Julien Chapuis; Florie Demiautte; Mathias Laga; Michel E Vandenberghe; Nicolas Malmanche; Florence Leroux; Fanny Eysert; Yoann Sottejeau; Linda Chami; Amandine Flaig; Charlotte Bauer; Pierre Dourlen; Marie Lesaffre; Charlotte Delay; Ludovic Huot; Julie Dumont; Elisabeth Werkmeister; Franck Lafont; Tiago Mendes; Franck Hansmannel; Bart Dermaut; Benoit Deprez; Anne-Sophie Hérard; Marc Dhenain; Nicolas Souedet; Florence Pasquier; David Tulasne; Claudine Berr; Jean-Jacques Hauw; Yves Lemoine; Philippe Amouyel; David Mann; Rebecca Déprez; Frédéric Checler; David Hot; Thierry Delzescaux; Kris Gevaert; Jean-Charles Lambert
Journal:  EBioMedicine       Date:  2016-06-02       Impact factor: 8.143
  5 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.