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Literature DB >> 25134928

A bifunctional curcumin analogue for two-photon imaging and inhibiting crosslinking of amyloid beta in Alzheimer's disease.

Xueli Zhang¹, Yanli Tian, Peng Yuan, Yuyan Li, Mohammad A Yaseen, Jaime Grutzendler, Anna Moore, Chongzhao Ran.

Abstract

In this report, we designed a highly bright bifunctional curcumin analogue CRANAD-28. In vivo two-photon imaging suggested that CRANAD-28 could penetrate the blood brain barrier (BBB) and label plaques and cerebral amyloid angiopathies (CAAs). We also demonstrated that this imaging probe could inhibit the crosslinking of amyloid beta induced either by copper or by natural conditions.

Entities: Chemical Disease Gene Species

Mesh：

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Year: 2014 PMID： 25134928 PMCID： PMC4617557 DOI： 10.1039/c4cc03731f

Source DB: PubMed Journal: Chem Commun (Camb) ISSN： 1359-7345 Impact factor: 6.222

37 in total

Review 1. Covalent and noncovalent phthalocyanine-carbon nanostructure systems: synthesis, photoinduced electron transfer, and application to molecular photovoltaics.

Authors: Giovanni Bottari; Gema de la Torre; Dirk M Guldi; Tomás Torres
Journal: Chem Rev Date: 2010-04-05 Impact factor: 60.622

2. A craniotomy surgery procedure for chronic brain imaging.

Authors: Ricardo Mostany; Carlos Portera-Cailliau
Journal: J Vis Exp Date: 2008-02-15 Impact factor: 1.355

3. Heme binding induces dimerization and nitration of truncated β-amyloid peptide Aβ16 under oxidative stress.

Authors: Grégory Thiabaud; Silvia Pizzocaro; Ricardo Garcia-Serres; Jean-Marc Latour; Enrico Monzani; Luigi Casella
Journal: Angew Chem Int Ed Engl Date: 2013-06-20 Impact factor: 15.336

4. PET-FCS: probing rapid structural fluctuations of proteins and nucleic acids by single-molecule fluorescence quenching.

Authors: Markus Sauer; Hannes Neuweiler
Journal: Methods Mol Biol Date: 2014

5. Spectral unmixing imaging of wavelength-responsive fluorescent probes: an application for the real-time report of amyloid Beta species in Alzheimer's disease.

Authors: Chongzhao Ran; Anna Moore
Journal: Mol Imaging Biol Date: 2012-06 Impact factor: 3.488

6. Mechanisms of quenching of Alexa fluorophores by natural amino acids.

Authors: Huimin Chen; Syed S Ahsan; Mitk'El B Santiago-Berrios; Hector D Abruña; Watt W Webb
Journal: J Am Chem Soc Date: 2010-06-02 Impact factor: 15.419

7. Resolving controversies on the path to Alzheimer's therapeutics.

Authors: Dennis J Selkoe
Journal: Nat Med Date: 2011-09-07 Impact factor: 53.440

Review 8. Nanoparticle-based theranostic agents.

Authors: Jin Xie; Seulki Lee; Xiaoyuan Chen
Journal: Adv Drug Deliv Rev Date: 2010-08-04 Impact factor: 15.470

9. Copper mediates dityrosine cross-linking of Alzheimer's amyloid-beta.

Authors: Craig S Atwood; George Perry; Hong Zeng; Yoji Kato; Walton D Jones; Ke-Qing Ling; Xudong Huang; Robert D Moir; Dandan Wang; Lawrence M Sayre; Mark A Smith; Shu G Chen; Ashley I Bush
Journal: Biochemistry Date: 2004-01-20 Impact factor: 3.162

10. Non-conjugated small molecule FRET for differentiating monomers from higher molecular weight amyloid beta species.

Authors: Chongzhao Ran; Wei Zhao; Robert D Moir; Anna Moore
Journal: PLoS One Date: 2011-04-29 Impact factor: 3.240

19 in total

1. Near-infrared fluorescence molecular imaging of amyloid beta species and monitoring therapy in animal models of Alzheimer's disease.

Authors: Xueli Zhang; Yanli Tian; Can Zhang; Xiaoyu Tian; Alana W Ross; Robert D Moir; Hongbin Sun; Rudolph E Tanzi; Anna Moore; Chongzhao Ran
Journal: Proc Natl Acad Sci U S A Date: 2015-07-21 Impact factor: 11.205

2. A comparative study of dietary curcumin, nanocurcumin, and other classical amyloid-binding dyes for labeling and imaging of amyloid plaques in brain tissue of 5×-familial Alzheimer's disease mice.

Authors: Panchanan Maiti; Tia C Hall; Leela Paladugu; Nivya Kolli; Cameron Learman; Julien Rossignol; Gary L Dunbar
Journal: Histochem Cell Biol Date: 2016-07-12 Impact factor: 4.304

10. Discovery of novel PDE9 inhibitors capable of inhibiting Aβ aggregation as potential candidates for the treatment of Alzheimer's disease.

Authors: Tao Su; Tianhua Zhang; Shishun Xie; Jun Yan; Yinuo Wu; Xingshu Li; Ling Huang; Hai-Bin Luo
Journal: Sci Rep Date: 2016-02-25 Impact factor: 4.379

A bifunctional curcumin analogue for two-photon imaging and inhibiting crosslinking of amyloid beta in Alzheimer's disease.

Review 1. Covalent and noncovalent phthalocyanine-carbon nanostructure systems: synthesis, photoinduced electron transfer, and application to molecular photovoltaics.

2. A craniotomy surgery procedure for chronic brain imaging.

3. Heme binding induces dimerization and nitration of truncated β-amyloid peptide Aβ16 under oxidative stress.

4. PET-FCS: probing rapid structural fluctuations of proteins and nucleic acids by single-molecule fluorescence quenching.

5. Spectral unmixing imaging of wavelength-responsive fluorescent probes: an application for the real-time report of amyloid Beta species in Alzheimer's disease.

6. Mechanisms of quenching of Alexa fluorophores by natural amino acids.

7. Resolving controversies on the path to Alzheimer's therapeutics.

Review 8. Nanoparticle-based theranostic agents.

9. Copper mediates dityrosine cross-linking of Alzheimer's amyloid-beta.

10. Non-conjugated small molecule FRET for differentiating monomers from higher molecular weight amyloid beta species.

1. Near-infrared fluorescence molecular imaging of amyloid beta species and monitoring therapy in animal models of Alzheimer's disease.

2. A comparative study of dietary curcumin, nanocurcumin, and other classical amyloid-binding dyes for labeling and imaging of amyloid plaques in brain tissue of 5×-familial Alzheimer's disease mice.

Review 3. Microglia-Mediated Neuroprotection, TREM2, and Alzheimer's Disease: Evidence From Optical Imaging.

Review 4. Targeting β-amyloid plaques and oligomers: development of near-IR fluorescence imaging probes.

Review 5. Advances in development of fluorescent probes for detecting amyloid-β aggregates.

Review 6. Curcumin in Health and Diseases: Alzheimer's Disease and Curcumin Analogues, Derivatives, and Hybrids.

7. Oxalate-curcumin-based probe for micro- and macroimaging of reactive oxygen species in Alzheimer's disease.

Review 8. Chalcone and its analogs: Therapeutic and diagnostic applications in Alzheimer's disease.

9. Microglia constitute a barrier that prevents neurotoxic protofibrillar Aβ42 hotspots around plaques.

10. Discovery of novel PDE9 inhibitors capable of inhibiting Aβ aggregation as potential candidates for the treatment of Alzheimer's disease.