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Literature DB >> 2513485

Inhibition by phospholipids of the interaction between R-ras, rho, and their GTPase-activating proteins.

Abstract

Certain lipids were found to inhibit the interaction between rho and R-ras proteins and their respective GTPase-activating proteins (GAP). Inhibitory lipids were similar for each protein but differed significantly from those previously found to inhibit the interaction between ras protein and GAP activity. These data raise the possibility that ras and related proteins are controlled biologically by interactions between lipids and GAP molecules.

Entities: Chemical

Mesh：

Substances：

Year: 1989 PMID： 2513485 PMCID： PMC363684 DOI： 10.1128/mcb.9.11.5260-5264.1989

Source DB: PubMed Journal: Mol Cell Biol ISSN： 0270-7306 Impact factor: 4.272

19 in total

1. A cytoplasmic protein stimulates normal N-ras p21 GTPase, but does not affect oncogenic mutants.

Authors: M Trahey; F McCormick
Journal: Science Date: 1987-10-23 Impact factor: 47.728

2. Structure of the human and murine R-ras genes, novel genes closely related to ras proto-oncogenes.

Authors: D G Lowe; D J Capon; E Delwart; A Y Sakaguchi; S L Naylor; D V Goeddel
Journal: Cell Date: 1987-01-16 Impact factor: 41.582

3. Mutational analysis of a ras catalytic domain.

Authors: B M Willumsen; A G Papageorge; H F Kung; E Bekesi; T Robins; M Johnsen; W C Vass; D R Lowy
Journal: Mol Cell Biol Date: 1986-07 Impact factor: 4.272

4. Identification of effector residues and a neutralizing epitope of Ha-ras-encoded p21.

Authors: I S Sigal; J B Gibbs; J S D'Alonzo; E M Scolnick
Journal: Proc Natl Acad Sci U S A Date: 1986-07 Impact factor: 11.205

Review 5. ras genes.

Authors: M Barbacid
Journal: Annu Rev Biochem Date: 1987 Impact factor: 23.643

6. Requirement for ras proto-oncogene function during serum-stimulated growth of NIH 3T3 cells.

Authors: L S Mulcahy; M R Smith; D W Stacey
Journal: Nature Date: 1985 Jan 17-23 Impact factor: 49.962

7. All ras proteins are polyisoprenylated but only some are palmitoylated.

Authors: J F Hancock; A I Magee; J E Childs; C J Marshall
Journal: Cell Date: 1989-06-30 Impact factor: 41.582

8. Growth factor-like action of phosphatidic acid.

Authors: W H Moolenaar; W Kruijer; B C Tilly; I Verlaan; A J Bierman; S W de Laat
Journal: Nature Date: 1986 Sep 11-17 Impact factor: 49.962

9. Direct activation of calcium-activated, phospholipid-dependent protein kinase by tumor-promoting phorbol esters.

Authors: M Castagna; Y Takai; K Kaibuchi; K Sano; U Kikkawa; Y Nishizuka
Journal: J Biol Chem Date: 1982-07-10 Impact factor: 5.157

10. A novel ras-related gene family.

Authors: P Madaule; R Axel
Journal: Cell Date: 1985-05 Impact factor: 41.582

17 in total

Review 1. The biochemistry of ras p21.

Authors: R J Grand; D Owen
Journal: Biochem J Date: 1991-11-01 Impact factor: 3.857

2. TRPV4 mediates tumor-derived endothelial cell migration via arachidonic acid-activated actin remodeling.

Authors: A Fiorio Pla; H L Ong; K T Cheng; A Brossa; B Bussolati; T Lockwich; B Paria; L Munaron; I S Ambudkar
Journal: Oncogene Date: 2011-06-20 Impact factor: 9.867

3. Serum stimulation of NIH 3T3 cells induces the production of lipids able to inhibit GTPase-activating protein activity.

Authors: C L Yu; M H Tsai; D W Stacey
Journal: Mol Cell Biol Date: 1990-12 Impact factor: 4.272

4. The Ras-related protein R-ras interacts directly with Raf-1 in a GTP-dependent manner.

Authors: M Spaargaren; G A Martin; F McCormick; M J Fernandez-Sarabia; J R Bischoff
Journal: Biochem J Date: 1994-06-01 Impact factor: 3.857

5. Identification of the guanine nucleotide dissociation stimulator for Ral as a putative effector molecule of R-ras, H-ras, K-ras, and Rap.

Authors: M Spaargaren; J R Bischoff
Journal: Proc Natl Acad Sci U S A Date: 1994-12-20 Impact factor: 11.205

10. Lysophosphatidic acid activation of phosphatidylcholine-hydrolysing phospholipase D and actin polymerization by a pertussis toxin-sensitive mechanism.

Authors: K S Ha; E J Yeo; J H Exton
Journal: Biochem J Date: 1994-10-01 Impact factor: 3.857