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Literature DB >> 25134820

Treatment of camptocormia with continuous subcutaneous infusions of apomorphine: 1-year prospective pilot study.

Katerina Mensikova¹, Michaela Kaiserova, Miroslav Vastik, Sandra Kurcova, Petr Kanovsky.

Abstract

Camptocormia is defined as a marked dystonic flexion of the trunk in the sagittal plane. Camptocormia responds poorly to botulinum toxin injections, manipulation with dopaminergic treatment, and deep brain stimulation. We designed a prospective pilot study to assess the effect of apomorphine infusions on camptocormia. Five patients were enrolled. All five patients responded well to this treatment. The fact that camptocormia responds so well to apomorphine may be explained by the sustained stimulation of the ventrolateral striatal D1 receptors, alleviating this type of dystonia.

Entities: Chemical Disease Species

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Year: 2014 PMID： 25134820 DOI： 10.1007/s00702-014-1297-9

Source DB: PubMed Journal: J Neural Transm (Vienna) ISSN： 0300-9564 Impact factor: 3.575

22 in total

1. Camptocormia (bent spine) in patients with Parkinson's disease--characterization and possible pathogenesis of an unusual phenomenon.

Authors: R Djaldetti; R Mosberg-Galili; H Sroka; D Merims; E Melamed
Journal: Mov Disord Date: 1999-05 Impact factor: 10.338

2. Parkinson's disease with camptocormia.

Authors: F Bloch; J L Houeto; S Tezenas du Montcel; F Bonneville; F Etchepare; M L Welter; S Rivaud-Pechoux; V Hahn-Barma; T Maisonobe; C Behar; J Y Lazennec; E Kurys; I Arnulf; A M Bonnet; Y Agid
Journal: J Neurol Neurosurg Psychiatry Date: 2006-06-05 Impact factor: 10.154

3. Continuous subcutaneous waking day apomorphine in the long term treatment of levodopa induced interdose dyskinesias in Parkinson's disease.

Authors: A Colzi; K Turner; A J Lees
Journal: J Neurol Neurosurg Psychiatry Date: 1998-05 Impact factor: 10.154

4. Unusual case of levodopa-responsive camptocormia in a patient with negative dopamine transporter scan and normal DYT 5 gene.

Authors: Srivadee Oravivattanakul; Hesham Abboud; Hubert Fernandez; Ilia Itin
Journal: Clin Neuropharmacol Date: 2014 Mar-Apr Impact factor: 1.592

5. Long-term effect of repeated lidocaine injections into the external oblique for upper camptocormia in Parkinson's disease.

Authors: Yoshihiko Furusawa; Yohei Mukai; Tomoya Kawazoe; Terunori Sano; Harumasa Nakamura; Chikako Sakamoto; Yasuyuki Iwata; Mizuki Wakita; Yasuhiro Nakata; Kohei Kamiya; Yoko Kobayashi; Takashi Sakamoto; Yoshihisa Takiyama; Miho Murata
Journal: Parkinsonism Relat Disord Date: 2012-10-05 Impact factor: 4.891

Treatment of camptocormia with continuous subcutaneous infusions of apomorphine: 1-year prospective pilot study.

1. Camptocormia (bent spine) in patients with Parkinson's disease--characterization and possible pathogenesis of an unusual phenomenon.

2. Parkinson's disease with camptocormia.

3. Continuous subcutaneous waking day apomorphine in the long term treatment of levodopa induced interdose dyskinesias in Parkinson's disease.

4. Unusual case of levodopa-responsive camptocormia in a patient with negative dopamine transporter scan and normal DYT 5 gene.

5. Long-term effect of repeated lidocaine injections into the external oblique for upper camptocormia in Parkinson's disease.

6. Motor outcome of dystonic camptocormia treated with pallidal neurostimulation.

7. Pisa syndrome in Parkinson's disease: an electrophysiological and imaging study.

8. Botulinum toxin treatment of lateral axial dystonia in Parkinsonism.

9. Subcutaneous apomorphine in late stage Parkinson's disease: a long term follow up.

10. Clinical factors associated with abnormal postures in Parkinson's disease.

Review 1. Managing Gait, Balance, and Posture in Parkinson's Disease.

Review 2. Current Concepts in the Treatment of Multiple System Atrophy.

Review 3. Pathophysiological Concepts and Treatment of Camptocormia.