Literature DB >> 25132665

Highly active macromolecular prodrugs inhibit expression of the hepatitis C virus genome in the host cells.

Pau Ruiz-Sanchis1, Benjamin M Wohl, Anton A A Smith, Kaja Zuwala, Jesper Melchjorsen, Martin Tolstrup, Alexander N Zelikin.   

Abstract

Efficacious, potent, and at the same time nontoxic macromolecular prodrugs of ribavirin are designed taking advantage over prodrug activation by the intracellular milieu. Activity of these prodrugs is illustrated in the cells hosting hepatitis C virus replication and also in the cells implicated in the inflammatory response to the viral infection.
© 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Entities:  

Keywords:  drug delivery; hepatitis C virus; polymers; prodrugs

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Substances：

Year:  2014        PMID： 25132665     DOI： 10.1002/adhm.201400307

Source DB:  PubMed          Journal:  Adv Healthc Mater        ISSN： 2192-2640            Impact factor:   9.933


  3 in total

Review 1.  Advanced Prodrug Strategies in Nucleoside and Non-Nucleoside Antiviral Agents: A Review of the Recent Five Years.

Authors:  Hanadi Sinokrot; Tasneem Smerat; Anas Najjar; Rafik Karaman
Journal:  Molecules       Date:  2017-10-16       Impact factor: 4.411

2.  Macromolecular prodrugs of ribavirin: Polymer backbone defines blood safety, drug release, and efficacy of anti-inflammatory effects.

Authors:  Kaja Zuwala; Camilla F Riber; Kaja Borup Løvschall; Anna H F Andersen; Lise Sørensen; Paulina Gajda; Martin Tolstrup; Alexander N Zelikin
Journal:  J Control Release       Date:  2018-02-09       Impact factor: 9.776

3.  HIV anti-latency treatment mediated by macromolecular prodrugs of histone deacetylase inhibitor, panobinostat.

Authors:  Kaja Zuwala; Anton A A Smith; Martin Tolstrup; Alexander N Zelikin
Journal:  Chem Sci       Date:  2016-01-05       Impact factor: 9.825
  3 in total

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