Literature DB >> 25132277

Surgery of the vulva in vulvar cancer.

Leonardo Micheletti1, Mario Preti2.   

Abstract

The standard radical mutilating surgery for the treatment of invasive vulval carcinoma is, today, being replaced by a conservative and individualised approach. Surgical conservative modifications that are currently considered safe, regarding vulval lesion, are separate skin vulval-groin incisions, drawn according to the lesion diameter, and wide local radical excision or partial radical vulvectomy with 1-2 cm of clinically clear surgical margins. Regarding inguinofemoral lymph nodes management, surgical conservative modifications not compromising patient survival are omission of groin lymphadenectomy only when tumour stromal invasion is ≤ 1 mm, unilateral groin lymphadenectomy only in well-lateralised early lesions and total or radical inguinofemoral lymphadenectomy with preservation of femoral fascia when full groin resection is needed. Sentinel lymph node dissection is a promising technique but it should not be routinely employed outside referral centres. Pelvic nodes are better managed by radiation. Locally advanced vulval carcinoma can be managed by ultraradical surgery, exclusive radiotherapy or chemoradiation.
Copyright © 2014 Elsevier Ltd. All rights reserved.

Entities:  

Keywords:  conservative surgery; groin anatomy; treatment development; vulval cancer

Mesh:

Year:  2014        PMID: 25132277     DOI: 10.1016/j.bpobgyn.2014.07.011

Source DB:  PubMed          Journal:  Best Pract Res Clin Obstet Gynaecol        ISSN: 1521-6934            Impact factor:   5.237


  13 in total

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Journal:  Wien Med Wochenschr       Date:  2015-05-01

2.  Adjuvant Radiation in Early Stage Vulvar Cancer: A Review of Indications and Optimal Dose.

Authors:  Karishma Khullar; Tomas Patrich; Salma K Jabbour; Lara Hathout
Journal:  Appl Radiat Oncol       Date:  2022-03

3.  Characteristics and outcomes for patients with advanced vaginal or vulvar cancer referred to a phase I clinical trials program: the MD Anderson cancer center experience.

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Journal:  Gynecol Oncol Res Pract       Date:  2015-11-14

4.  Interstitial high-dose-rate brachytherapy in locally advanced and recurrent vulvar cancer.

Authors:  Sylwia Kellas-Ślęczka; Brygida Białas; Marek Fijałkowski; Piotr Wojcieszek; Marta Szlag; Agnieszka Cholewka; Maciej Ślęczka; Zofia Kołosza
Journal:  J Contemp Brachytherapy       Date:  2016-02-29

5.  MRI evaluation of vulvar squamous-cell carcinoma in fresh radical local excision specimens for cancer localization and prediction of surgical tumor-free margins.

Authors:  Jan Heidkamp; Petra L M Zusterzeel; Adriana C H van Engen-van Grunsven; Christiaan G Overduin; Andor Veltien; Arie Maat; Maroeska M Rovers; Jurgen J Fütterer
Journal:  NMR Biomed       Date:  2018-11-15       Impact factor: 4.044

Review 6.  Is There a Place for Immune Checkpoint Inhibitors in Vulvar Neoplasms? A State of the Art Review.

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Journal:  Int J Mol Sci       Date:  2020-12-27       Impact factor: 5.923

7.  Perineural Invasion in Vulvar Squamous-Cell Carcinoma Is an Independent Risk Factor for Cancer-Specific Survival, but Not for Locoregional Recurrence: Results from a Single Tertiary Referral Center.

Authors:  Leonardo Micheletti; Fulvio Borella; Mario Preti; Valentina Frau; Stefano Cosma; Sebastiana Privitera; Luca Bertero; Chiara Benedetto
Journal:  Cancers (Basel)       Date:  2021-12-28       Impact factor: 6.639

Review 8.  Electroporation and Electrochemotherapy in Gynecological and Breast Cancer Treatment.

Authors:  Zofia Łapińska; Urszula Szwedowicz; Anna Choromańska; Jolanta Saczko
Journal:  Molecules       Date:  2022-04-12       Impact factor: 4.927

9.  Treatment Outcomes of Patients with Squamous Cell Carcinoma of the Vulva: The Largest Series from a Tertiary Care Hospital.

Authors:  Panida Meelapkij; Prapaporn Suprasert; Orthai Baisai
Journal:  Obstet Gynecol Int       Date:  2018-09-03

10.  Comparison of two types of the triple incision technique in the treatment of patients with locally advanced vulvar cancer.

Authors:  Ying Ma; Wei-Feng Liang; Chang-Hao Liu; Zhong-Qiu Lin; Miao-Fang Wu; Jing Li
Journal:  Int J Med Sci       Date:  2020-09-16       Impact factor: 3.738

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