Literature DB >> 2513223

Lysosomal mutations increase susceptibility to anaesthetics.

F Ahmed1, L G Lundin, J G Shire.   

Abstract

The anaesthetic responses of homozygous mutant mice were compared with those of their normal heterozygous littermates. The two recessive mutations studied were beige (bg) and reduced pigmentation (rp). Homozygosity for either significantly increased the sleeping time of both sexes after treatment with pentobarbital, tribromoethanol or the steroid anaesthetic alphaxalone.

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Year:  1989        PMID： 2513223     DOI： 10.1007/bf01950180

Source DB:  PubMed          Journal:  Experientia        ISSN： 0014-4754


  10 in total

1.  Inheritance of reaction to halothane anaesthesia in pigs.

Authors:  C Smith; P R Bampton
Journal:  Genet Res       Date:  1977-06       Impact factor: 1.588

2.  Volatile general anaesthetics activate a novel neuronal K+ current.

Authors:  N P Franks; W R Lieb
Journal:  Nature       Date:  1988-06-16       Impact factor: 49.962

3.  The P450 gene superfamily: recommended nomenclature.

Authors:  D W Nebert; M Adesnik; M J Coon; R W Estabrook; F J Gonzalez; F P Guengerich; I C Gunsalus; E F Johnson; B Kemper; W Levin
Journal:  DNA       Date:  1987-02

4.  Lysosomal mutations inhibit lipofuscinosis of the spleen in C57BL mice.

Authors:  F Ahmed; J G Shire
Journal:  J Hered       Date:  1985 Jul-Aug       Impact factor: 2.645

5.  Reduced pigmentation (rp), a new coat colour gene with effects on kidney lysosomal glycosidases in the mouse.

Authors:  S Gibb; E M Håkansson; L G Lundin; J G Shire
Journal:  Genet Res       Date:  1981-02       Impact factor: 1.588

6.  C57BL/6J-bgJ (beige) mice: differential sensitivity in the tail flick test to centrally administered mu- and delta-opioid receptor agonists.

Authors:  J R Mathiasen; R B Raffa; J L Vaught
Journal:  Life Sci       Date:  1987-05-18       Impact factor: 5.037

7.  General anesthetics can competitively interfere with sensitive membrane proteins.

Authors:  P W Tas; H G Kress; K Koschel
Journal:  Proc Natl Acad Sci U S A       Date:  1987-08       Impact factor: 11.205

8.  Pigment mutations in the mouse which also affect lysosomal functions lead to suppressed natural killer cell activity.

Authors:  A Orn; E M Håkansson; M Gidlund; U Ramstedt; I Axberg; H Wigzell; L G Lundin
Journal:  Scand J Immunol       Date:  1982-03       Impact factor: 3.487

9.  Platelet storage pool deficiency in mouse pigment mutations associated with seven distinct genetic loci.

Authors:  E K Novak; S W Hui; R T Swank
Journal:  Blood       Date:  1984-03       Impact factor: 22.113

10.  Variation in pentobarbitone sleeping time in mice. 1. Strain and sex differences.

Authors:  D P Lovell
Journal:  Lab Anim       Date:  1986-04       Impact factor: 2.471
  10 in total
  2 in total

1.  Molecular markers near two mouse chromosome 13 genes, muted and pearl, which cause platelet storage pool deficiency (SPD).

Authors:  E P O'Brien; E K Novak; L Zhen; K F Manly; D Stephenson; R T Swank
Journal:  Mamm Genome       Date:  1995-01       Impact factor: 2.957

2.  Molecular map of chromosome 19 including three genes affecting bleeding time: ep, ru, and bm.

Authors:  E P O'Brien; E K Novak; S A Keller; C Poirier; J L Guénet; R T Swank
Journal:  Mamm Genome       Date:  1994-06       Impact factor: 2.957
  2 in total

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