Mehmet Yavuz Gözükara1, Abdurrezzak Börekçi2, Mustafa Gür2, Nurten Aksoy3, Taner Şeker4, Onur Kaypaklı4, Hakan Uçar4, Caner Türkoğlu5, Mevlüt Koç4, İlyas Makca4, Selahattin Akyol4, Şahbettin Selek6, Murat Çaylı4. 1. Department of Internal Medicine, Mersin State Hospital, Mersin, Turkey. 2. Department of Cardiology, Faculty of Medicine, Kafkas University, Kars, Turkey. 3. Department of Clinical Biochemistry, Faculty of Medicine, Harran University, Şanlıurfa, Turkey. 4. Department of Cardiology, Adana Numune Training and Research Hospital, Adana, Turkey. 5. Department of Cardiology, Ankara Yenimahalle State Hospital, Ankara, Turkey. 6. Department of Clinical Biochemistry, Bezmialem Vakıf University, İstanbul, Turkey.
Abstract
BACKGROUND: We aimed to investigate relationship between gamma glutamyl transferase (GGT) activity with paraoxonase 1 (PON1) activity and aortic stiffness (AS) parameters such as pulse wave velocity (PWV) and augmentation index (AIx). METHODS: Measurements were obtained from 324 patients with newly diagnosed essential hypertension (mean age: 55.0 ± 8.2 years). The patients were divided into two groups according to their median GGT values. PWV and AIx were calculated using the single-point method via the Mobil-O-Graph® ARCsolver algorithm. RESULTS: PWV, Aix, and high-sensitive C-reactive protein (hs-CRP) values were higher and PON1 activity values were lower in GGThigh group compared with GGTlow group (P < 0.05, for all). Multiple linear regression analysis showed that GGT activity was independently associated with PWV (β = 0.496, P < 0.001) and PON1 activity (β = -0.343, P < 0.001) as well as hs-CRP (β = 0.334, P < 0.001). CONCLUSION: These results may support that increased GGT activity would be associated with both impaired antioxidant system and increased AS in hypertensive patients.
BACKGROUND: We aimed to investigate relationship between gamma glutamyl transferase (GGT) activity with paraoxonase 1 (PON1) activity and aortic stiffness (AS) parameters such as pulse wave velocity (PWV) and augmentation index (AIx). METHODS: Measurements were obtained from 324 patients with newly diagnosed essential hypertension (mean age: 55.0 ± 8.2 years). The patients were divided into two groups according to their median GGT values. PWV and AIx were calculated using the single-point method via the Mobil-O-Graph® ARCsolver algorithm. RESULTS: PWV, Aix, and high-sensitive C-reactive protein (hs-CRP) values were higher and PON1 activity values were lower in GGThigh group compared with GGTlow group (P < 0.05, for all). Multiple linear regression analysis showed that GGT activity was independently associated with PWV (β = 0.496, P < 0.001) and PON1 activity (β = -0.343, P < 0.001) as well as hs-CRP (β = 0.334, P < 0.001). CONCLUSION: These results may support that increased GGT activity would be associated with both impaired antioxidant system and increased AS in hypertensivepatients.
Authors: N B Schiller; P M Shah; M Crawford; A DeMaria; R Devereux; H Feigenbaum; H Gutgesell; N Reichek; D Sahn; I Schnittger Journal: J Am Soc Echocardiogr Date: 1989 Sep-Oct Impact factor: 5.251
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Authors: S Wassertheurer; J Kropf; T Weber; M van der Giet; J Baulmann; M Ammer; B Hametner; C C Mayer; B Eber; D Magometschnigg Journal: J Hum Hypertens Date: 2010-03-18 Impact factor: 3.012