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Literature DB >> 25131621

Liquid formulation for antibody drugs.

Abstract

Currently many biopharmaceuticals are in use due to their high efficacy and low adverse effects. For antibody drug formulation, liquid ones are being increasingly used. This review focuses on rational liquid antibody formulation development based on the proposed aggregation mechanism of antibody, considering colloidal and conformational stabilities. This review also describes the importance of assessment of physicochemical properties including second virial coefficient of antibody solutions, for the rational and efficient formulation development. This article is part of a Special Issue entitled: Recent advances in molecular engineering of antibody.

Keywords: Aggregation; Antibody; Colloidal stability; Conformational stability; Formulation; Virial coefficient

Year: 2014 PMID： 25131621 DOI： 10.1016/j.bbapap.2014.07.016

Source DB: PubMed Journal: Biochim Biophys Acta ISSN： 0006-3002

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Cited

14 in total

1. Assessment of the Protein-Protein Interactions in a Highly Concentrated Antibody Solution by Using Raman Spectroscopy.

Authors: Chikashi Ota; Shintaro Noguchi; Satoru Nagatoishi; Kouhei Tsumoto
Journal: Pharm Res Date: 2015-12-16 Impact factor: 4.200

Review 2. Advanced protein formulations.

Authors: Wei Wang
Journal: Protein Sci Date: 2015-05-01 Impact factor: 6.725

3. Infliximab crystal structures reveal insights into self-association.

Authors: Thomas F Lerch; Penelope Sharpe; Stephen J Mayclin; Thomas E Edwards; Eunhee Lee; Hugh D Conlon; Sharon Polleck; Jason C Rouse; Yin Luo; Qin Zou
Journal: MAbs Date: 2017-04-19 Impact factor: 5.857

4. Predicting Protein-Protein Interactions of Concentrated Antibody Solutions Using Dilute Solution Data and Coarse-Grained Molecular Models.

Authors: Cesar Calero-Rubio; Ranendu Ghosh; Atul Saluja; Christopher J Roberts
Journal: J Pharm Sci Date: 2017-12-21 Impact factor: 3.534

Review 5. Sedimentation velocity analytical ultracentrifugation for characterization of therapeutic antibodies.

Authors: Susumu Uchiyama; Masanori Noda; Elena Krayukhina
Journal: Biophys Rev Date: 2017-12-14

6. Biophysical characterization and molecular simulation of electrostatically driven self-association of a single-chain antibody.

Authors: Christopher J O'Brien; Cesar Calero-Rubio; Vladimir I Razinkov; Anne S Robinson; Christopher J Roberts
Journal: Protein Sci Date: 2018-05-03 Impact factor: 6.725

7. ANTISOMA: A Computational Pipeline for the Reduction of the Aggregation Propensity of Monoclonal Antibodies.

Authors: Katerina C Nastou; Eleftheria G Karataraki; Nikos C Papandreou; Anna-Isavella G Rerra; Vassiliki P Grimanelli; Ilias Maglogiannis; Stavros J Hamodrakas; Vassiliki A Iconomidou
Journal: Adv Exp Med Biol Date: 2020 Impact factor: 2.622

8. Nanoparticulate Impurities in Pharmaceutical-Grade Sugars and their Interference with Light Scattering-Based Analysis of Protein Formulations.

Authors: Daniel Weinbuch; Jason K Cheung; Jurgen Ketelaars; Vasco Filipe; Andrea Hawe; John den Engelsman; Wim Jiskoot
Journal: Pharm Res Date: 2015-01-30 Impact factor: 4.200

9. Improved Stability of a Model IgG3 by DoE-Based Evaluation of Buffer Formulations.

Authors: Brittany K Chavez; Cyrus D Agarabi; Erik K Read; Michael T Boyne; Mansoor A Khan; Kurt A Brorson
Journal: Biomed Res Int Date: 2016-03-03 Impact factor: 3.411

10. Efficient generation of single domain antibodies with high affinities and enhanced thermal stabilities.

Authors: Naoya Shinozaki; Ryuji Hashimoto; Kiichi Fukui; Susumu Uchiyama
Journal: Sci Rep Date: 2017-07-19 Impact factor: 4.379