Literature DB >> 25131454

Testicular hypofunction and multiple sclerosis risk: a record-linkage study.

Julia Pakpoor1, Raph Goldacre, Klaus Schmierer, Gavin Giovannoni, Michael J Goldacre.   

Abstract

The influence of gonadal hormones on multiple sclerosis (MS) is not well characterized and has thus far been investigated primarily in animal models or as a proposed therapeutic approach. We investigated a potential association between testicular hypofunction, as a proxy for low testosterone levels, and MS risk through analysis of linked English national Hospital Episode Statistics from 1999 to 2011. We report a strong positive association between testicular hypofunction and subsequent MS (rate ratio = 4.62, 95% confidence interval = 2.3-8.24, p < 0.0001). Future work should aim more directly to elucidate the relationship between testosterone levels and MS in both males and females.
© 2014 American Neurological Association.

Entities:  

Mesh：

Year:  2014        PMID： 25131454     DOI： 10.1002/ana.24250

Source DB:  PubMed          Journal:  Ann Neurol        ISSN： 0364-5134            Impact factor:   10.422


  11 in total

1.  Low testosterone and myasthenia gravis in males: a national record-linkage study.

Authors:  Julia Pakpoor; Raph Goldacre; Michael J Goldacre
Journal:  J Neurol       Date:  2016-10-24       Impact factor: 4.849

Review 2.  The importance of studying sex differences in disease: The example of multiple sclerosis.

Authors:  Lisa C Golden; Rhonda Voskuhl
Journal:  J Neurosci Res       Date:  2017-01-02       Impact factor: 4.164

Review 3.  Multiple sclerosis in men: management considerations.

Authors:  Riley Bove; Allison McHenry; Kerstin Hellwig; Maria Houtchens; Neda Razaz; Penelope Smyth; Helen Tremlett; A D Sadovnick; D Rintell
Journal:  J Neurol       Date:  2016-01-02       Impact factor: 4.849

Review 4.  Male infertility and somatic health - insights into lipid damage as a mechanistic link.

Authors:  Nathan D Burke; Brett Nixon; Shaun D Roman; John E Schjenken; Jessica L H Walters; R John Aitken; Elizabeth G Bromfield
Journal:  Nat Rev Urol       Date:  2022-09-13       Impact factor: 16.430

5.  The 2D:4D ratio, a proxy for prenatal androgen levels, differs in men with and without MS.

Authors:  Riley Bove; Muhammed T Malik; Camilo Diaz-Cruz; Alicia Chua; Taylor J Saraceno; David Bargiela; Emily Greeke; Bonnie I Glanz; Brian C Healy; Tanuja Chitnis
Journal:  Neurology       Date:  2015-09-04       Impact factor: 9.910

6.  Unexpected central role of the androgen receptor in the spontaneous regeneration of myelin.

Authors:  Bartosz Bielecki; Claudia Mattern; Abdel M Ghoumari; Sumaira Javaid; Kaja Smietanka; Charly Abi Ghanem; Sakina Mhaouty-Kodja; M Said Ghandour; Etienne-Emile Baulieu; Robin J M Franklin; Michael Schumacher; Elisabeth Traiffort
Journal:  Proc Natl Acad Sci U S A       Date:  2016-12-07       Impact factor: 11.205

Review 7.  Emerging Approaches for Validating and Managing Multiple Sclerosis Relapse.

Authors:  Elizabeth A Mills; Ali Mirza; Yang Mao-Draayer
Journal:  Front Neurol       Date:  2017-03-29       Impact factor: 4.003

8.  Associations between clinically diagnosed testicular hypofunction and systemic lupus erythematosus: a record linkage study.

Authors:  Julia Pakpoor; Raph Goldacre; Michael J Goldacre
Journal:  Clin Rheumatol       Date:  2017-11-03       Impact factor: 2.980

9.  Hormone-related diseases and prostate cancer: An English national record linkage study.

Authors:  Eleanor L Watts; Raphael Goldacre; Timothy J Key; Naomi E Allen; Ruth C Travis; Aurora Perez-Cornago
Journal:  Int J Cancer       Date:  2019-12-11       Impact factor: 7.396

10.  Quetiapine has an additive effect to triiodothyronine in inducing differentiation of oligodendrocyte precursor cells through induction of cholesterol biosynthesis.

Authors:  Jaime Gonzalez Cardona; Matthew D Smith; Jingya Wang; Leslie Kirby; Jason T Schott; Todd Davidson; Jodi L Karnell; Katharine A Whartenby; Peter A Calabresi
Journal:  PLoS One       Date:  2019-09-06       Impact factor: 3.240
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