M S Helfer1, A R Vicari2, F Spuldaro2, L F S Gonçalves3, R C Manfro4. 1. School of Medicine, Federal University of Rio Grande do Sul, Brazil. 2. Division of Nephrology, Renal Transplant Unit, Hospital de Clínicas de Porto Alegre, Brazil. 3. School of Medicine, Federal University of Rio Grande do Sul, Brazil; Division of Nephrology, Renal Transplant Unit, Hospital de Clínicas de Porto Alegre, Brazil. 4. School of Medicine, Federal University of Rio Grande do Sul, Brazil; Division of Nephrology, Renal Transplant Unit, Hospital de Clínicas de Porto Alegre, Brazil. Electronic address: rmanfro@hcpa.ufrgs.br.
Abstract
BACKGROUND: A high incidence of delayed graft function (DGF) after deceased donor kidney transplantation occurs in Brazil. The reasons for such have not been adequately studied. METHODS: We performed a retrospective cohort study of 346 kidney transplant recipients from deceased donors. DGF risk factors related to the recipient, donor, and transplantation surgery were analyzed and correlated with graft outcomes. A logistic regression analysis was used to identify independent risk factors and patient and graft survival were assessed using Kaplan-Meier curves. RESULTS: The incidence of DGF was 70.8% (245 cases). Our final model of multivariate analysis showed that DGF is associated (P < .05) with donor final serum creatinine (relative risk [RR], 1.84; 95% confidence interval [CI], 1.26-2.70), donor age (RR, 1.02 [1.0-1.033]), receiving a kidney from national offer (RR, 2.44 [1.06-5.59]), and need for antibody induction (RR, 2.87 [1.33-6.18]). Outcomes that were associated with DGF were longer length of hospital stay (32.5 ± 20.5 vs 18.8 ± 16.3 days; P = .01), higher incidence of acute rejection (37.8 vs 12.9%; P < .01), worse graft survival at 1 year (83.5% vs 93.9%; P < .01), and higher levels of serum creatinine at 3, 6, and 12 months (P < .05). There was no difference in patient survival and the occurrence of acute rejection did not influence the survival of patients or grafts. CONCLUSION: DGF was associated with higher donor final serum creatinine, donor age, receiving a kidney from the national supply, and need for antibody induction. Most importantly, DGF was associated with worse outcomes.
BACKGROUND: A high incidence of delayed graft function (DGF) after deceased donor kidney transplantation occurs in Brazil. The reasons for such have not been adequately studied. METHODS: We performed a retrospective cohort study of 346 kidney transplant recipients from deceased donors. DGF risk factors related to the recipient, donor, and transplantation surgery were analyzed and correlated with graft outcomes. A logistic regression analysis was used to identify independent risk factors and patient and graft survival were assessed using Kaplan-Meier curves. RESULTS: The incidence of DGF was 70.8% (245 cases). Our final model of multivariate analysis showed that DGF is associated (P < .05) with donor final serum creatinine (relative risk [RR], 1.84; 95% confidence interval [CI], 1.26-2.70), donor age (RR, 1.02 [1.0-1.033]), receiving a kidney from national offer (RR, 2.44 [1.06-5.59]), and need for antibody induction (RR, 2.87 [1.33-6.18]). Outcomes that were associated with DGF were longer length of hospital stay (32.5 ± 20.5 vs 18.8 ± 16.3 days; P = .01), higher incidence of acute rejection (37.8 vs 12.9%; P < .01), worse graft survival at 1 year (83.5% vs 93.9%; P < .01), and higher levels of serum creatinine at 3, 6, and 12 months (P < .05). There was no difference in patient survival and the occurrence of acute rejection did not influence the survival of patients or grafts. CONCLUSION: DGF was associated with higher donor final serum creatinine, donor age, receiving a kidney from the national supply, and need for antibody induction. Most importantly, DGF was associated with worse outcomes.
Authors: N Gopalakrishnan; T Dineshkumar; J Dhanapriya; R Sakthirajan; T Balasubramaniyan; N D Srinivasa Prasad; K Thirumalvalavan; S Murugananth; K Kawaskar Journal: Indian J Nephrol Date: 2017 Jan-Feb
Authors: Maria Helena Calixto Fernandes; Thomas Schricker; Sheldon Magder; Roupen Hatzakorzian Journal: Crit Care Date: 2018-01-25 Impact factor: 9.097
Authors: Silvana Daher Costa; Luis Gustavo Modelli de Andrade; Francisco Victor Carvalho Barroso; Cláudia Maria Costa de Oliveira; Elizabeth De Francesco Daher; Paula Frassinetti Castelo Branco Camurça Fernandes; Ronaldo de Matos Esmeraldo; Tainá Veras de Sandes-Freitas Journal: PLoS One Date: 2020-02-06 Impact factor: 3.240