[Effects of conditioned media of rat pleural mesothelial cells, transformed in vivo or in vitro by asbestos, on the proliferation of normal mesothelial cells. Comparison with epidermal growth factor, EGF].

The effect of conditioned media obtained from in vivo or in vitro asbestos-transformed rat pleural mesothelial cells on growth of normal mesothelial cells was studied. It was found that both conditioned media led to a reduction of cell proliferation as shown by a decrease in the following parameters: cell number, tritiated thymidine incorporation and percentages of S cells. Similar effects were obtained with EGF (Epidermal Growth Factor).