OBJECTIVES: This study focused on the expression pattern and clinical significance of B7-H3 expression in human acute leukemia. METHODS: We systematically analyzed 134 patients with acute myeloid leukemia (101 cases) and acute lymphocytic leukemia (33 cases) by flow cytometry. RESULTS: The frequency of B7-H3(+) cases was 44.8% in total. The B7-H3 expression rate differed from 0% to 74.8% in individual cases. The correlation between B7-H3 expression and traditional prognostic factors, such as age and gender, the white blood cell count was not confirmed. However, B7-H3 had a significant higher expression in CD34(+) cases and high risk karyotypes. CONCLUSIONS: Owing to the expression of B7-H3 being statistically relevant in predicting disease progression and a shorter life survival, our results demonstrated that B7-H3 expression in acute leukemia predicts an unfavorable outcome.
OBJECTIVES: This study focused on the expression pattern and clinical significance of B7-H3 expression in human acute leukemia. METHODS: We systematically analyzed 134 patients with acute myeloid leukemia (101 cases) and acute lymphocytic leukemia (33 cases) by flow cytometry. RESULTS: The frequency of B7-H3(+) cases was 44.8% in total. The B7-H3 expression rate differed from 0% to 74.8% in individual cases. The correlation between B7-H3 expression and traditional prognostic factors, such as age and gender, the white blood cell count was not confirmed. However, B7-H3 had a significant higher expression in CD34(+) cases and high risk karyotypes. CONCLUSIONS: Owing to the expression of B7-H3 being statistically relevant in predicting disease progression and a shorter life survival, our results demonstrated that B7-H3 expression in acute leukemia predicts an unfavorable outcome.
Authors: Sunitha V Bachawal; Kristin C Jensen; Katheryne E Wilson; Lu Tian; Amelie M Lutz; Jürgen K Willmann Journal: Cancer Res Date: 2015-04-21 Impact factor: 12.701
Authors: Hongxia Li; Emily B Harrison; Huizhong Li; Koichi Hirabayashi; Jing Chen; Qi-Xiang Li; Jared Gunn; Jared Weiss; Barbara Savoldo; Joel S Parker; Chad V Pecot; Gianpietro Dotti; Hongwei Du Journal: Nat Commun Date: 2022-04-20 Impact factor: 17.694