Literature DB >> 25130540

Complete protection against lethal challenge of novel H7N9 virus with heterologous inactivated H7 vaccine in mice.

Lay Hoon Tang1, Jie Hui Lim1, Li Fang Kuah1, Yuk Fai Lau2.   

Abstract

A prototype H7 influenza vaccine constructed based on the H7N7 outbreak in 2003 was tested for the protective efficacy against the novel H7N9 virus in a lethal murine challenge model. Serum samples from vaccinated mice showed significant neutralizing activity against the H7N9 virus and the mice were completely protected with no significant weight loss. The results have direct implications on how to overcome potential vaccine shortage and identify donors for immune sera for passive immunization.
Copyright © 2014 Elsevier Ltd. All rights reserved.

Entities:  

Keywords:  H7N9; Influenza; Vaccine

Mesh：

Substances：

Year:  2014        PMID： 25130540     DOI： 10.1016/j.vaccine.2014.07.087

Source DB:  PubMed          Journal:  Vaccine        ISSN： 0264-410X            Impact factor:   3.641


  5 in total

1.  Induction of protective immunity against influenza A/Jiangxi-Donghu/346/2013 (H10N8) in mice.

Authors:  Li-Fang Kuah; Lay-Hoon Tang; Troy Sutton; Jie-Hui Lim; Wan-Ling Sin; Elaine Lamirande; Kanta Subbarao; Yuk-Fai Lau
Journal:  J Gen Virol       Date:  2017-03-13       Impact factor: 3.891

2.  Refining the approach to vaccines against influenza A viruses with pandemic potential.

Authors:  Rita Czako; Kanta Subbarao
Journal:  Future Virol       Date:  2015       Impact factor: 1.831

3.  Immunogenicity and protective efficacy of a Vero cell culture-derived whole-virus H7N9 vaccine in mice and guinea pigs.

Authors:  Walter Wodal; Michael G Schwendinger; Helga Savidis-Dacho; Brian A Crowe; Christine Hohenadl; Richard Fritz; Peter Brühl; Daniel Portsmouth; Anita Karner-Pichl; Dalida Balta; Leopold Grillberger; Otfried Kistner; P Noel Barrett; M Keith Howard
Journal:  PLoS One       Date:  2015-02-26       Impact factor: 3.240

4.  Oral immunization with a novel attenuated Salmonella Typhimurium encoding influenza HA, M2e and NA antigens protects chickens against H7N9 infection.

Authors:  Je Hyoung Kim; Irshad Ahmed Hajam; John Hwa Lee
Journal:  Vet Res       Date:  2018-02-01       Impact factor: 3.683

5.  Two genetically diverse H7N7 avian influenza viruses isolated from migratory birds in central China.

Authors:  Haizhou Liu; Chaochao Xiong; Jing Chen; Guang Chen; Jun Zhang; Yong Li; Yanping Xiong; Runkun Wang; Ying Cao; Quanjiao Chen; Di Liu; Hanzhong Wang; Jianjun Chen
Journal:  Emerg Microbes Infect       Date:  2018-04-11       Impact factor: 7.163
  5 in total

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