Andrea Dell'Amore1, Marco Monteverde2, Nicola Martucci3, Fabio Davoli4, Guido Caroli5, Emanuela Pipitone6, Alessandro Bini5, Franco Stella5, Davide Dell'Amore2, Caterina Casadio4, Gaetano Rocco3. 1. Division of Thoracic Surgery, S.Orsola Malpighi University Hospital, Bologna, Italy. Electronic address: dellamore76@libero.it. 2. Division of Thoracic Surgery, Morgagni Pierantoni Hospital, Forlì, Italy. 3. Division of Thoracic Surgery, Istituto Nazionale dei Tumori, IRCCS Fondazione Pascale, Naples, Italy. 4. Division of Thoracic Surgery, University Eastern Piedmont, Novara, Italy. 5. Division of Thoracic Surgery, S.Orsola Malpighi University Hospital, Bologna, Italy. 6. Department of Formative Science, University of Modena and Reggio Emilia, Modena, Italy.
Abstract
BACKGROUND: Non-small cell lung cancer (NSCLC) in young adults is uncommon. The objective of this study was to evaluate the clinicopathological characteristics, outcomes and prognosis of people younger than 50 years old treated surgically for NSCLC. METHODS: A retrospective study was conducted using the institutional database of four thoracic surgery units to collect patients with NSCLC younger than 50 years who had undergone surgery. These patients were compared with older patients (>75-years) operated in the same institutions and in the same period. RESULTS: We identified 113 young patients and 347 older patients. Younger patients were more likely to be female, non-smokers, with fewer comorbidities. Younger patients were more likely to be symptomatic at the time of diagnosis. Risk factors for poor prognosis in younger patients were T-stage, and disease-free-interval less than 548 days. Kaplan-Meier analysis showed a lower five-year survival in older patients compared with the younger ones (66% vs 38%, p=0.001). CONCLUSIONS: In conclusion NSCLC in younger patients has some distinct clinicopathological characteristics. The overall-survival of young patients is better than in older patients. Young patients receive more complete and aggressive treatment that could explain better survival. Further prospective studies with larger patient populations are required, to clarify the biological and genetic variance of NSCLC in younger patients.
BACKGROUND:Non-small cell lung cancer (NSCLC) in young adults is uncommon. The objective of this study was to evaluate the clinicopathological characteristics, outcomes and prognosis of people younger than 50 years old treated surgically for NSCLC. METHODS: A retrospective study was conducted using the institutional database of four thoracic surgery units to collect patients with NSCLC younger than 50 years who had undergone surgery. These patients were compared with older patients (>75-years) operated in the same institutions and in the same period. RESULTS: We identified 113 young patients and 347 older patients. Younger patients were more likely to be female, non-smokers, with fewer comorbidities. Younger patients were more likely to be symptomatic at the time of diagnosis. Risk factors for poor prognosis in younger patients were T-stage, and disease-free-interval less than 548 days. Kaplan-Meier analysis showed a lower five-year survival in older patients compared with the younger ones (66% vs 38%, p=0.001). CONCLUSIONS: In conclusion NSCLC in younger patients has some distinct clinicopathological characteristics. The overall-survival of young patients is better than in older patients. Young patients receive more complete and aggressive treatment that could explain better survival. Further prospective studies with larger patient populations are required, to clarify the biological and genetic variance of NSCLC in younger patients.
Authors: Sarah Cullivan; Sarah Ni Mhaolcatha; Michael T Henry; Nazri Kaderi Muhammad; William Mullally; Richard M Bambury; Louise Burke; Marcus P Kennedy Journal: Transl Cancer Res Date: 2019-08 Impact factor: 1.241