Eun-Jin Jang1, Su-Mi Cha2, Sung-Mi Choi3, Jeong-Dan Cha4. 1. Department of Dental Technology, Daegu Health College, Daegu, South Korea. 2. Department of Oral Microbiology and Institute of Oral Bioscience, Chonbuk National University, Jeonju, South Korea. 3. Department of Dental Hygiene, Daegu Health College, Daegu, South Korea. 4. Department of Natural Product Research, Institute of Jinan red ginseng, Jinan, South Korea. Electronic address: joungdan@chonbuk.ac.kr.
Abstract
BACKGROUND: Baicalein is one of the major flavonoids in Scutellaria baicalensis Georgi, which has long been used in Asia as herbal medicine. Several biological effects of baicalein, such as antiviral, anti-inflammatiom, anti-hepatotoxicity, and anti-tumour properties, have been reported. OBJECTIVE AND DESIGN: In this study, the antibacterial activities of baicalein were investigated in combination with ampicillin and/or gentamicin against oral bacteria. RESULTS: Baicalein was determined with MIC and MBC values ranging from 80 to 320 and 160 to 640 μg/mL against oral bacteria. The range of MIC₅₀ and MIC₉₀ were 20-160 μg/mL and 80-320 μg/mL, respectively. The combination effects of baicalein with antibiotics were synergistic (FIC index <0.375-0.5 and FBCI <0.5) against oral bacteria. Furthermore, a time-kill study showed that the growth of the tested bacteria was completely attenuated after 1-6 h of treatment with the MIC₅₀ of baicalein, regardless of whether it was administered alone or with ampicillin or gentamicin. CONCLUSION: These results suggest that baicalein combined with other antibiotics may be microbiologically beneficial and not antagonistic.
BACKGROUND:Baicalein is one of the major flavonoids in Scutellaria baicalensis Georgi, which has long been used in Asia as herbal medicine. Several biological effects of baicalein, such as antiviral, anti-inflammatiom, anti-hepatotoxicity, and anti-tumour properties, have been reported. OBJECTIVE AND DESIGN: In this study, the antibacterial activities of baicalein were investigated in combination with ampicillin and/or gentamicin against oral bacteria. RESULTS:Baicalein was determined with MIC and MBC values ranging from 80 to 320 and 160 to 640 μg/mL against oral bacteria. The range of MIC₅₀ and MIC₉₀ were 20-160 μg/mL and 80-320 μg/mL, respectively. The combination effects of baicalein with antibiotics were synergistic (FIC index <0.375-0.5 and FBCI <0.5) against oral bacteria. Furthermore, a time-kill study showed that the growth of the tested bacteria was completely attenuated after 1-6 h of treatment with the MIC₅₀ of baicalein, regardless of whether it was administered alone or with ampicillin or gentamicin. CONCLUSION: These results suggest that baicalein combined with other antibiotics may be microbiologically beneficial and not antagonistic.
Authors: Ken Cham-Fai Leung; Chaminda Jayampath Seneviratne; Xuan Li; Ping Chung Leung; Clara Bik San Lau; Chi-Hin Wong; Ka Yan Pang; Chun Wai Wong; Elaine Wat; Lijian Jin Journal: Nanomaterials (Basel) Date: 2016-04-07 Impact factor: 5.076
Authors: Xian Zhou; Sai Wang Seto; Dennis Chang; Hosen Kiat; Valentina Razmovski-Naumovski; Kelvin Chan; Alan Bensoussan Journal: Front Pharmacol Date: 2016-07-12 Impact factor: 5.810