Literature DB >> 2512924

Cloning of human gene encoding prostaglandin endoperoxide synthase and primary structure of the enzyme.

C Yokoyama1, T Tanabe.   

Abstract

The complete amino acid sequence of human prostaglandin endoperoxide synthase (EC 1.14.99.1, cyclooxygenase) was deduced by cloning and sequence analysis of human genomic DNA coding for the enzyme. The isolated clones covered approximately 40 kilobase pairs of human gene and the protein coding region of the enzyme was distributed into eleven exons, which encoded 599 amino acid residues with a calculated molecular weight of 68,548. Human prostaglandin endoperoxide synthase exhibited 91% amino acid identity with the sheep enzyme.

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Year:  1989        PMID： 2512924     DOI： 10.1016/s0006-291x(89)80049-x

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  41 in total

1.  Synergistic induction of cyclooxygenase-2 by transforming growth factor-beta1 and epidermal growth factor inhibits apoptosis in epithelial cells.

Authors:  D Saha; P K Datta; H Sheng; J D Morrow; M Wada; H L Moses; R D Beauchamp
Journal:  Neoplasia       Date:  1999-12       Impact factor: 5.715

Review 2.  Regulation of intracellular cyclooxygenase levels by gene transcription and protein degradation.

Authors:  Yeon-Joo Kang; Uri R Mbonye; Cynthia J DeLong; Masayuki Wada; William L Smith
Journal:  Prog Lipid Res       Date:  2007-01-18       Impact factor: 16.195

3.  Acute effects of the anti-inflammatory cyclooxygenase-2 selective inhibitor, flosulide, on renal plasma flow and glomerular filtration rate in rats.

Authors:  A Turull; C Piera; J Queralt
Journal:  Inflammation       Date:  2001-04       Impact factor: 4.092

4.  New nucleotide sequence data on the EMBL File Server.

Authors: 
Journal:  Nucleic Acids Res       Date:  1990-08-25       Impact factor: 16.971

5.  A human whole blood assay for clinical evaluation of biochemical efficacy of cyclooxygenase inhibitors.

Authors:  C Brideau; S Kargman; S Liu; A L Dallob; E W Ehrich; I W Rodger; C C Chan
Journal:  Inflamm Res       Date:  1996-02       Impact factor: 4.575

6.  Effect of a cyclooxygenase-2 inhibitor on postexercise muscle protein synthesis in humans.

Authors:  Nicholas A Burd; Jared M Dickinson; Jennifer K Lemoine; Chad C Carroll; Bridget E Sullivan; Jacob M Haus; Bozena Jemiolo; Scott W Trappe; Gordon M Hughes; Charles E Sanders; Todd A Trappe
Journal:  Am J Physiol Endocrinol Metab       Date:  2009-11-24       Impact factor: 4.310

Review 7.  Bioactive lipids in Trypanosoma cruzi infection.

Authors:  Fabiana S Machado; Shankar Mukherjee; Louis M Weiss; Herbert B Tanowitz; Anthony W Ashton
Journal:  Adv Parasitol       Date:  2011       Impact factor: 3.870

8.  Proliferation-dependent changes in release of arachidonic acid from endothelial cells.

Authors:  R E Whatley; K Satoh; G A Zimmerman; T M McIntyre; S M Prescott
Journal:  J Clin Invest       Date:  1994-11       Impact factor: 14.808

9.  Expression of a mitogen-responsive gene encoding prostaglandin synthase is regulated by mRNA splicing.

Authors:  W L Xie; J G Chipman; D L Robertson; R L Erikson; D L Simmons
Journal:  Proc Natl Acad Sci U S A       Date:  1991-04-01       Impact factor: 11.205

10.  Cyclooxygenase-2 deficiency enhances Th2 immune responses and impairs neutrophil recruitment in hepatic ischemia/reperfusion injury.

Authors:  Takashi Hamada; Seiichiro Tsuchihashi; Armine Avanesyan; Sergio Duarte; Carolina Moore; Ronald W Busuttil; Ana J Coito
Journal:  J Immunol       Date:  2008-02-01       Impact factor: 5.422
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