| Literature DB >> 25128423 |
Hai-Yan Wu1, Wei-Guang Wang2, Hua-Yi Jiang1, Xue Du2, Xiao-Nian Li2, Jian-Xin Pu3, Han-Dong Sun4.
Abstract
Seven new ent-kaurane diterpenoids, isowikstroemins A-G (1-7), were isolated from EtOAc extracts of the aerial parts of Isodon wikstroemioides. Their structures were elucidated by extensive spectroscopic analysis. The isolates were evaluated for their cytotoxicity against five human tumor cell lines, and compounds 1-4 exhibited significant activity with IC50 values ranging from 0.9 to 7.0 μM. In addition, compounds 1, 2, 3, 4, and 7 exhibited inhibitory activity against nitric oxide (NO) production in LPS-activated RAW264.7 macrophages.Entities:
Keywords: Cytotoxicity; Isodon wikstroemioides; Lamiaceae; ent-Kaurane diterpenoid
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Year: 2014 PMID： 25128423 DOI： 10.1016/j.fitote.2014.08.012
Source DB: PubMed Journal: Fitoterapia ISSN： 0367-326X Impact factor: 2.882