| Literature DB >> 25127055 |
Johnathan Canton1, Sergio Grinstein2.
Abstract
In mammals, engagement of Toll-like receptors by microbe-associated molecular patterns enhances the responsiveness of NADPH oxidases. Two recent papers report a similar 'priming' mechanism for the plant oxidase RbohD. Despite lacking structural homology, the functional parallels between plants and animals reveal that a common regulatory logic arose by convergent evolution.Keywords: NADPH oxidase; NOX; PAMP; ROS; RbohD; TLR; pattern recognition receptor; priming; reactive oxygen species
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Year: 2014 PMID: 25127055 DOI: 10.1016/j.it.2014.07.007
Source DB: PubMed Journal: Trends Immunol ISSN: 1471-4906 Impact factor: 16.687