Literature DB >> 2512697

GTP-binding proteins as possible targets for protein kinase C action.

R Sagi-Eisenberg.   

Abstract

The alpha-subunits of two guanine nucleotide binding proteins Gi and transducin, as well as the beta-subunit of transducin, serve as substrates for phosphorylation by the Ca2+- and phospholipid-dependent protein kinase C (PKC). Phosphorylation of the alpha-subunit of transducin is strictly dependent on its conformation and it is only the inactive form that is subjected to phosphorylation by PKC. This review will focus on the proposition that G proteins may serve as cellular targets for modulatory actions of PKC.

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Year:  1989        PMID： 2512697     DOI： 10.1016/0968-0004(89)90001-7

Source DB:  PubMed          Journal:  Trends Biochem Sci        ISSN： 0968-0004            Impact factor:   13.807


  13 in total

1.  Purification and characterization of G proteins from human brain: modification of GTPase activity upon phosphorylation.

Authors:  C Sauvage; J F Rumigny; M Maitre
Journal:  Mol Cell Biochem       Date:  1991-09-18       Impact factor: 3.396

Review 2.  The role of G proteins in transmembrane signalling.

Authors:  C W Taylor
Journal:  Biochem J       Date:  1990-11-15       Impact factor: 3.857

3.  Systems analysis in cell biology: from the phenomenological description towards a computer model of the intracellular signal transduction network.

Authors:  M Kraus; P Lais; B Wolf
Journal:  Experientia       Date:  1993-03-15

4.  Shape changes, exocytosis, and cytosolic free calcium changes in stimulated human eosinophils.

Authors:  P Kernen; M P Wymann; V von Tscharner; D A Deranleau; P C Tai; C J Spry; C A Dahinden; M Baggiolini
Journal:  J Clin Invest       Date:  1991-06       Impact factor: 14.808

5.  Evidence for regulation of human platelet adenylate cyclase by phosphorylation. Inhibition by ATP and guanosine 5'-[beta-thio]diphosphate occur by distinct mechanisms.

Authors:  I A Wadman; R W Farndale; B R Martin
Journal:  Biochem J       Date:  1991-06-15       Impact factor: 3.857

6.  Homologous and unique G protein alpha subunits in the nematode Caenorhabditis elegans.

Authors:  M A Lochrie; J E Mendel; P W Sternberg; M I Simon
Journal:  Cell Regul       Date:  1991-02

7.  Possible role of cGMP in excitatory amino acid induced cytotoxicity in cultured cerebral cortical neurons.

Authors:  A Frandsen; C F Andersen; A Schousboe
Journal:  Neurochem Res       Date:  1992-01       Impact factor: 3.996

8.  Functional alterations of G-proteins in diabetic rat retina: a possible explanation for the early visual abnormalities in diabetes mellitus.

Authors:  A Kowluru; R A Kowluru; A Yamazaki
Journal:  Diabetologia       Date:  1992-07       Impact factor: 10.122

9.  Analysis of protein kinase C requirement for exocytosis in permeabilized rat basophilic leukaemia RBL-2H3 cells: a GTP-binding protein(s) as a potential target for protein kinase C.

Authors:  R Buccione; G Di Tullio; M Caretta; M R Marinetti; C Bizzarri; S Francavilla; A Luini; M A De Matteis
Journal:  Biochem J       Date:  1994-02-15       Impact factor: 3.857

10.  GTP and noradrenaline-induced force in isolated toxin-permeabilized rat anococcygeus and guinea-pig portal vein.

Authors:  C A Crichton; G L Smith
Journal:  J Physiol       Date:  1991-06       Impact factor: 5.182
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