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Literature DB >> 25126736

Autophagy deficiency stabilizes TWIST1 to promote epithelial-mesenchymal transition.

Abstract

The transcription factor TWIST1 is a basic helix-loop-helix protein that regulates epithelial-mesenchymal transition (EMT) in early embryonic morphogenesis, cancer development, and cancer metastasis. The regulation of TWIST1 remains poorly understood. Recently, we found that autophagy deficiency stabilizes TWIST1 protein through SQSTM1/p62 accumulation. SQSTM1 binds with TWIST1 to inhibit TWIST1 degradation in both autophagosomes and proteasomes. SQSTM1-mediated TWIST1 stabilization promotes EMT in vitro, and tumor growth and metastasis in mice. We propose autophagy as a new mechanism to control the TWIST1 protein levels and activity in cancer development and progression.

Entities: Disease Gene Species

Keywords: EMT; TWIST1; autophagosome; autophagy; melanoma; metastasis; p62; proteasome; skin cancer; tumor growth

Mesh：

Substances：

Year: 2014 PMID： 25126736 PMCID： PMC4198370 DOI： 10.4161/auto.32171

Source DB: PubMed Journal: Autophagy ISSN： 1554-8627 Impact factor: 16.016

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Cited

27 in total

1. Chemotactic G protein-coupled receptors control cell migration by repressing autophagosome biogenesis.

Authors: Pierre-Michaël Coly; Nicolas Perzo; Vadim Le Joncour; Céline Lecointre; Marie-Thérèse Schouft; Laurence Desrues; Marie-Christine Tonon; Olivier Wurtz; Pierrick Gandolfo; Hélène Castel; Fabrice Morin
Journal: Autophagy Date: 2016-10-07 Impact factor: 16.016

Review 2. Autophagy and Hallmarks of Cancer.

Authors: Tianzhi Huang; Xiao Song; Yongyong Yang; Xuechao Wan; Angel A Alvarez; Namratha Sastry; Haizhong Feng; Bo Hu; Shi-Yuan Cheng
Journal: Crit Rev Oncog Date: 2018

3. Sestrin2 protein positively regulates AKT enzyme signaling and survival in human squamous cell carcinoma and melanoma cells.

Authors: Baozhong Zhao; Palak Shah; Andrei V Budanov; Lei Qiang; Mei Ming; Andrew Aplin; Diane M Sims; Yu-Ying He
Journal: J Biol Chem Date: 2014-11-06 Impact factor: 5.157

4. Metalloprotease-dependent activation of EGFR modulates CD44⁺/CD24^- populations in triple negative breast cancer cells through the MEK/ERK pathway.

Authors: Randi Wise; Anna Zolkiewska
Journal: Breast Cancer Res Treat Date: 2017-08-08 Impact factor: 4.872

5. The dicyano compound induces autophagic or apoptotic cell death via Twist/c-Myc axis depending on metastatic characteristics of breast cancer cells.

Authors: Ozge Alvur; Hakan Kucuksayan; Yasemin Baygu; Nilgun Kabay; Yasar Gok; Hakan Akca
Journal: Mol Biol Rep Date: 2021-11-13 Impact factor: 2.316

Review 10. Revisiting Epithelial-to-Mesenchymal Transition in Liver Fibrosis: Clues for a Better Understanding of the "Reactive" Biliary Epithelial Phenotype.

Authors: Luca Fabris; Simone Brivio; Massimiliano Cadamuro; Mario Strazzabosco
Journal: Stem Cells Int Date: 2016-01-06 Impact factor: 5.443

Autophagy deficiency stabilizes TWIST1 to promote epithelial-mesenchymal transition.

1. Chemotactic G protein-coupled receptors control cell migration by repressing autophagosome biogenesis.

Review 2. Autophagy and Hallmarks of Cancer.

3. Sestrin2 protein positively regulates AKT enzyme signaling and survival in human squamous cell carcinoma and melanoma cells.

4. Metalloprotease-dependent activation of EGFR modulates CD44⁺/CD24^- populations in triple negative breast cancer cells through the MEK/ERK pathway.

5. The dicyano compound induces autophagic or apoptotic cell death via Twist/c-Myc axis depending on metastatic characteristics of breast cancer cells.

Review 6. Signal pathways of melanoma and targeted therapy.

7. Autophagy inhibition promotes epithelial-mesenchymal transition through ROS/HO-1 pathway in ovarian cancer cells.

8. The importance of epithelial-mesenchymal transition and autophagy in cancer drug resistance.

Review 9. Epithelial-to-Mesenchymal Transition and Cancer Invasiveness: What Can We Learn from Cholangiocarcinoma?

Review 10. Revisiting Epithelial-to-Mesenchymal Transition in Liver Fibrosis: Clues for a Better Understanding of the "Reactive" Biliary Epithelial Phenotype.

Autophagy deficiency stabilizes TWIST1 to promote epithelial-mesenchymal transition.

1. Chemotactic G protein-coupled receptors control cell migration by repressing autophagosome biogenesis.

Review 2. Autophagy and Hallmarks of Cancer.

3. Sestrin2 protein positively regulates AKT enzyme signaling and survival in human squamous cell carcinoma and melanoma cells.

4. Metalloprotease-dependent activation of EGFR modulates CD44+/CD24- populations in triple negative breast cancer cells through the MEK/ERK pathway.

5. The dicyano compound induces autophagic or apoptotic cell death via Twist/c-Myc axis depending on metastatic characteristics of breast cancer cells.

Review 6. Signal pathways of melanoma and targeted therapy.

7. Autophagy inhibition promotes epithelial-mesenchymal transition through ROS/HO-1 pathway in ovarian cancer cells.

8. The importance of epithelial-mesenchymal transition and autophagy in cancer drug resistance.

Review 9. Epithelial-to-Mesenchymal Transition and Cancer Invasiveness: What Can We Learn from Cholangiocarcinoma?

Review 10. Revisiting Epithelial-to-Mesenchymal Transition in Liver Fibrosis: Clues for a Better Understanding of the "Reactive" Biliary Epithelial Phenotype.

4. Metalloprotease-dependent activation of EGFR modulates CD44⁺/CD24^- populations in triple negative breast cancer cells through the MEK/ERK pathway.