Yohei Mano 1 , Shinichi Aishima 2 , Yuichiro Kubo 2 , Yuki Tanaka 2 , Takashi Motomura 3 , Takeo Toshima 3 , Ken Shirabe 3 , Shingo Baba 4 , Yoshihiko Maehara 3 , Yoshinao Oda 5 Show Affiliations »
Abstract
OBJECTIVES: This study investigated the association between several biological markers and fluorine-18 fluorodeoxyglucose (FDG) uptake in patients with hepatocellular carcinoma. METHODS: Forty-two patients with hepatocellular carcinoma who underwent FDG positron emission tomography were included in the study. Tumor sections were immunohistochemically stained for phosphorylated signal transducer and activator of transcription 3 (pSTAT3), hypoxia-inducible factor 1α (HIF1α), glucose transporter 1 (GLUT1), GLUT2, GLUT3, and GLUT4. RESULTS: The high standardized uptake value (SUV) group showed larger tumor size, more frequent vascular invasion, and poorer differentiation compared with the low SUV group. The high SUV group also showed significantly higher immunohistochemical expression of pSTAT3, HIF1α, and GLUT1. The GLUT1 high-expression group showed higher α-fetoprotein (a tumor marker) and poorer differentiation than did the GLUT1 low-expression group. CONCLUSIONS: Our study indicates that FDG uptake is associated with the expression of pSTAT3, HIF1α, and GLUT1 in hepatocellular carcinoma. The expression of these proteins shows a correlation with poor differentiation and vascular invasion. Copyright© by the American Society for Clinical Pathology.
OBJECTIVES: This study investigated the association between several biological markers and fluorine-18 fluorodeoxyglucose (FDG ) uptake in patients with hepatocellular carcinoma . METHODS: Forty-two patients with hepatocellular carcinoma who underwent FDG positron emission tomography were included in the study. Tumor sections were immunohistochemically stained for phosphorylated signal transducer and activator of transcription 3 (pSTAT3), hypoxia-inducible factor 1α (HIF1α), glucose transporter 1 (GLUT1 ), GLUT2 , GLUT3 , and GLUT4 . RESULTS: The high standardized uptake value (SUV) group showed larger tumor size, more frequent vascular invasion, and poorer differentiation compared with the low SUV group. The high SUV group also showed significantly higher immunohistochemical expression of pSTAT3, HIF1α, and GLUT1 . The GLUT1 high-expression group showed higher α-fetoprotein (a tumor marker) and poorer differentiation than did the GLUT1 low-expression group. CONCLUSIONS: Our study indicates that FDG uptake is associated with the expression of pSTAT3, HIF1α, and GLUT1 in hepatocellular carcinoma . The expression of these proteins shows a correlation with poor differentiation and vascular invasion. Copyright© by the American Society for Clinical Pathology.
Entities: Chemical
Disease
Gene
Species
Keywords:
FDG positron emission tomography; GLUT1; HIF1α; Hepatocellular carcinoma; STAT3
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Year: 2014
PMID： 25125631 DOI： 10.1309/AJCPG8AFJ5NRKLLM
Source DB: PubMed Journal: Am J Clin Pathol ISSN： 0002-9173 Impact factor: 2.493