Alaina Borden1, David Wallon2, Romain Lefaucheur1, Stéphane Derrey3, Damien Fetter1, Marc Verin4, David Maltête5. 1. Department of Neurology, Rouen University Hospital, University of Rouen, France. 2. Department of Neurology, Rouen University Hospital, University of Rouen, France; Department of Neurosurgery, Rouen University Hospital, University of Rouen, France. 3. Department of Neurosurgery, Rouen University Hospital, University of Rouen, France. 4. Department of Neurology, University Hospital of Rennes, France; EA 4712 "Behavior and Basal Ganglia", Rennes 1 University, France. 5. Department of Neurology, Rouen University Hospital, University of Rouen, France; INSERM U1079, Rouen Faculty of Medicine, France. Electronic address: david.maltete@chu-rouen.fr.
Abstract
BACKGROUNDS: An early and transient verbal fluency (VF) decline and impairment in frontal executive function, suggesting a cognitive microlesion effect may influence the cognitive repercussions related to subthalamic nucleus deep brain stimulation (STN-DBS). METHODS: Neuropsychological tests including semantic and phonemic verbal fluency were administered both before surgery (baseline), the third day after surgery (T3), at six months (T180), and at an endpoint multiple years after surgery (Tyears). RESULTS: Twenty-four patients (mean age, 63.5 ± 9.5 years; mean disease duration, 12 ± 5.8 years) were included. Both semantic and phonemic VF decreased significantly in the acute post-operative period (44.4 ± 28.2% and 34.3 ± 33.4%, respectively) and remained low at 6 months compared to pre-operative levels (decrease of 3.4 ± 47.8% and 10.8 ± 32.1%) (P < 0.05). Regression analysis showed phonemic VF to be an independent factor of decreased phonemic VF at six months. Age was the only independent predictive factor for incident Parkinson's disease dementia (PDD) (F (4,19)=3.4, P<0.03). CONCLUSION: An acute post-operative decline in phonemic VF can be predictive of a long-term phonemic VF deficit. The severity of this cognitive lesion effect does not predict the development of dementia which appears to be disease-related.
BACKGROUNDS: An early and transient verbal fluency (VF) decline and impairment in frontal executive function, suggesting a cognitive microlesion effect may influence the cognitive repercussions related to subthalamic nucleus deep brain stimulation (STN-DBS). METHODS: Neuropsychological tests including semantic and phonemic verbal fluency were administered both before surgery (baseline), the third day after surgery (T3), at six months (T180), and at an endpoint multiple years after surgery (Tyears). RESULTS: Twenty-four patients (mean age, 63.5 ± 9.5 years; mean disease duration, 12 ± 5.8 years) were included. Both semantic and phonemic VF decreased significantly in the acute post-operative period (44.4 ± 28.2% and 34.3 ± 33.4%, respectively) and remained low at 6 months compared to pre-operative levels (decrease of 3.4 ± 47.8% and 10.8 ± 32.1%) (P < 0.05). Regression analysis showed phonemic VF to be an independent factor of decreased phonemic VF at six months. Age was the only independent predictive factor for incident Parkinson's disease dementia (PDD) (F (4,19)=3.4, P<0.03). CONCLUSION: An acute post-operative decline in phonemic VF can be predictive of a long-term phonemic VF deficit. The severity of this cognitive lesion effect does not predict the development of dementia which appears to be disease-related.
Authors: Venus Tang; Cannon X L Zhu; Danny Chan; Claire Lau; Anne Chan; Vincent Mok; Jonas Yeung; Wai Sang Poon Journal: Neurol Sci Date: 2015-02-24 Impact factor: 3.307
Authors: Valéria de Carvalho Fagundes; Carlos R M Rieder; Aline Nunes da Cruz; Bárbara Costa Beber; Mirna Wetters Portuguez Journal: Parkinsons Dis Date: 2016-12-05