AIM: Acute kidney injury (AKI) is one of the main causes of morbidity and mortality in cases of envenomation by venomous snakes. The present study was carried out to investigate the clinical and laboratory manifestations in accidents with venomous snakes and the risk factors associated with AKI in these accidents. METHODS: A retrospective study was carried out with patients victims of snakebite admitted to a reference centre. AKI was defined according to the RIFLE and AKIN criteria. RESULTS: A total of 276 patients were included, of which 230 (83.7%) were males. AKI was observed in 42 cases (15.2%). The mean genus involved in the accidents was Bothrops (82.2%). Mean age of patients with AKI was higher than in patients without AKI (43 ± 20 vs. 34 ± 21 years, P = 0.015). The time elapsed between the accident and medical care was higher in the AKI group (25 ± 28 vs. 14 ± 16h, P = 0.034), as well as the time elapsed between the accident and the administration of antivenom (30.7 ± 27 vs. 15 ± 16 h, P = 0.01). Haemodialysis was required in 30% of cases and complete renal function recovery was observed in 54.8% of cases at hospital discharge. There were four deaths, none of which had AKI. Factors associated with AKI were haemorrhagic abnormalities (P = 0.036, OR = 6.718, 95% CI: 1.067-25.661) and longer length of hospital stay (P = 0.004, OR = 1.69, 95% CI 1.165-2.088). CONCLUSION: Acute kidney injury is an important complication of snakebite accidents, showing low mortality, but high morbidity, which can lead to partial renal function recovery.
AIM: Acute kidney injury (AKI) is one of the main causes of morbidity and mortality in cases of envenomation by venomous snakes. The present study was carried out to investigate the clinical and laboratory manifestations in accidents with venomous snakes and the risk factors associated with AKI in these accidents. METHODS: A retrospective study was carried out with patients victims of snakebite admitted to a reference centre. AKI was defined according to the RIFLE and AKIN criteria. RESULTS: A total of 276 patients were included, of which 230 (83.7%) were males. AKI was observed in 42 cases (15.2%). The mean genus involved in the accidents was Bothrops (82.2%). Mean age of patients with AKI was higher than in patients without AKI (43 ± 20 vs. 34 ± 21 years, P = 0.015). The time elapsed between the accident and medical care was higher in the AKI group (25 ± 28 vs. 14 ± 16h, P = 0.034), as well as the time elapsed between the accident and the administration of antivenom (30.7 ± 27 vs. 15 ± 16 h, P = 0.01). Haemodialysis was required in 30% of cases and complete renal function recovery was observed in 54.8% of cases at hospital discharge. There were four deaths, none of which had AKI. Factors associated with AKI were haemorrhagic abnormalities (P = 0.036, OR = 6.718, 95% CI: 1.067-25.661) and longer length of hospital stay (P = 0.004, OR = 1.69, 95% CI 1.165-2.088). CONCLUSION:Acute kidney injury is an important complication of snakebite accidents, showing low mortality, but high morbidity, which can lead to partial renal function recovery.
Authors: Esaú L Feitosa; Vanderson S Sampaio; Jorge L Salinas; Amanda M Queiroz; Iran Mendonça da Silva; André A Gomes; Jacqueline Sachett; André M Siqueira; Luiz Carlos L Ferreira; Maria Cristina Dos Santos; Marcus Lacerda; Wuelton Monteiro Journal: PLoS One Date: 2015-07-13 Impact factor: 3.240
Authors: Jacqueline A G Sachett; Iran Mendonça da Silva; Eliane Campos Alves; Sâmella S Oliveira; Vanderson S Sampaio; Fábio Francesconi do Vale; Gustavo Adolfo Sierra Romero; Marcelo Cordeiro Dos Santos; Hedylamar Oliveira Marques; Mônica Colombini; Ana Maria Moura da Silva; Fan Hui Wen; Marcus V G Lacerda; Wuelton M Monteiro; Luiz C L Ferreira Journal: PLoS Negl Trop Dis Date: 2017-07-10
Authors: Eliane Campos Alves; Jacqueline de Almeida Gonçalves Sachett; Vanderson Souza Sampaio; José Diego de Brito Sousa; Sâmella Silva de Oliveira; Elizandra Freitas do Nascimento; Alessandra Dos Santos Santos; Iran Mendonça da Silva; Ana Maria Moura da Silva; Fan Hui Wen; Mônica Colombini; Marcus Vinicius Guimarães de Lacerda; Wuelton Marcelo Monteiro; Luiz Carlos de Lima Ferreira Journal: PLoS One Date: 2018-08-17 Impact factor: 3.240
Authors: Polianna Lemos Moura Moreira Albuquerque; Geraldo Bezerra da Silva Junior; Gdayllon Cavalcante Meneses; Alice Maria Costa Martins; Danya Bandeira Lima; Jacques Raubenheimer; Shihana Fathima; Nicholas Buckley; Elizabeth De Francesco Daher Journal: Toxins (Basel) Date: 2019-03-05 Impact factor: 4.546