Literature DB >> 25122135

Small molecule adenosine 5'-monophosphate activated protein kinase (AMPK) modulators and human diseases.

Sandeep Rana1, Elizabeth C Blowers, Amarnath Natarajan.   

Abstract

Adenosine 5'-monophosphate activated protein kinase (AMPK) is a master sensor of cellular energy status that plays a key role in the regulation of whole-body energy homeostasis. AMPK is a serine/threonine kinase that is activated by upstream kinases LKB1, CaMKKβ, and Tak1, among others. AMPK exists as αβγ trimeric complexes that are allosterically regulated by AMP, ADP, and ATP. Dysregulation of AMPK has been implicated in a number of metabolic diseases including type 2 diabetes mellitus and obesity. Recent studies have associated roles of AMPK with the development of cancer and neurological disorders, making it a potential therapeutic target to treat human diseases. This review focuses on the structure and function of AMPK, its role in human diseases, and its direct substrates and provides a brief synopsis of key AMPK modulators and their relevance in human diseases.

Entities:  

Mesh：

Substances：

Year:  2014        PMID： 25122135      PMCID： PMC4864506          DOI： 10.1021/jm401994c

Source DB:  PubMed          Journal:  J Med Chem        ISSN： 0022-2623            Impact factor:   7.446


  258 in total

1.  On the origin of cancer cells.

Authors:  O WARBURG
Journal:  Science       Date:  1956-02-24       Impact factor: 47.728

2.  Saponin rich fractions from Polygonatum odoratum (Mill.) Druce with more potential hypoglycemic effects.

Authors:  Yafei Deng; Kai He; Xiaoli Ye; Xin Chen; Jing Huang; Xuegang Li; Lujiang Yuan; Yalan Jin; Qing Jin; Panpan Li
Journal:  J Ethnopharmacol       Date:  2012-02-17       Impact factor: 4.360

3.  Novel small-molecule AMPK activator orally exerts beneficial effects on diabetic db/db mice.

Authors:  Yuan-Yuan Li; Li-Fang Yu; Li-Na Zhang; Bei-Ying Qiu; Ming-Bo Su; Fang Wu; Da-Kai Chen; Tao Pang; Min Gu; Wei Zhang; Wei-Ping Ma; Hao-Wen Jiang; Jing-Ya Li; Fa-Jun Nan; Jia Li
Journal:  Toxicol Appl Pharmacol       Date:  2013-09-18       Impact factor: 4.219

4.  AMP-activated protein kinase induces a p53-dependent metabolic checkpoint.

Authors:  Russell G Jones; David R Plas; Sara Kubek; Monica Buzzai; James Mu; Yang Xu; Morris J Birnbaum; Craig B Thompson
Journal:  Mol Cell       Date:  2005-04-29       Impact factor: 17.970

Review 5.  Rosiglitazone.

Authors:  J A Balfour; G L Plosker
Journal:  Drugs       Date:  1999-06       Impact factor: 9.546

6.  Anticancer effects of thiazolidinediones are independent of peroxisome proliferator-activated receptor gamma and mediated by inhibition of translation initiation.

Authors:  S S Palakurthi; H Aktas; L M Grubissich; R M Mortensen; J A Halperin
Journal:  Cancer Res       Date:  2001-08-15       Impact factor: 12.701

7.  Stimulation of rat liver AMP-activated protein kinase by AMP analogues.

Authors:  N Henin; M F Vincent; G Van den Berghe
Journal:  Biochim Biophys Acta       Date:  1996-06-04

8.  Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan.

Authors:  Konrad T Howitz; Kevin J Bitterman; Haim Y Cohen; Dudley W Lamming; Siva Lavu; Jason G Wood; Robert E Zipkin; Phuong Chung; Anne Kisielewski; Li-Li Zhang; Brandy Scherer; David A Sinclair
Journal:  Nature       Date:  2003-08-24       Impact factor: 49.962

9.  Structure of mammalian AMPK and its regulation by ADP.

Authors:  Bing Xiao; Matthew J Sanders; Elizabeth Underwood; Richard Heath; Faith V Mayer; David Carmena; Chun Jing; Philip A Walker; John F Eccleston; Lesley F Haire; Peter Saiu; Steven A Howell; Rein Aasland; Stephen R Martin; David Carling; Steven J Gamblin
Journal:  Nature       Date:  2011-03-13       Impact factor: 49.962

10.  Adiponectin stimulates glucose utilization and fatty-acid oxidation by activating AMP-activated protein kinase.

Authors:  T Yamauchi; J Kamon; Y Minokoshi; Y Ito; H Waki; S Uchida; S Yamashita; M Noda; S Kita; K Ueki; K Eto; Y Akanuma; P Froguel; F Foufelle; P Ferre; D Carling; S Kimura; R Nagai; B B Kahn; T Kadowaki
Journal:  Nat Med       Date:  2002-10-07       Impact factor: 53.440
View more
  13 in total

1.  Inhibition of AMP Kinase by the Protein Phosphatase 2A Heterotrimer, PP2APpp2r2d.

Authors:  Biny K Joseph; Hsing-Yin Liu; Jamie Francisco; Devanshi Pandya; Melissa Donigan; Christina Gallo-Ebert; Caroline Giordano; Adam Bata; Joseph T Nickels
Journal:  J Biol Chem       Date:  2015-02-18       Impact factor: 5.157

2.  Discovery of MK-8722: A Systemic, Direct Pan-Activator of AMP-Activated Protein Kinase.

Authors:  Danqing Feng; Tesfaye Biftu; F Anthony Romero; Ahmet Kekec; James Dropinski; Andrew Kassick; Shiyao Xu; Marc M Kurtz; Anantha Gollapudi; Qing Shao; Xiaodong Yang; Ku Lu; Gaochao Zhou; Daniel Kemp; Robert W Myers; Hong-Ping Guan; Maria E Trujillo; Cai Li; Ann Weber; Iyassu K Sebhat
Journal:  ACS Med Chem Lett       Date:  2017-12-01       Impact factor: 4.345

Review 3.  A concise review on advances in development of small molecule anti-inflammatory therapeutics emphasising AMPK: An emerging target.

Authors:  Chethan Gejjalagere Honnappa; Unnikrishnan Mazhuvancherry Kesavan
Journal:  Int J Immunopathol Pharmacol       Date:  2016-10-05       Impact factor: 3.219

4.  Development of Potent Adenosine Monophosphate Activated Protein Kinase (AMPK) Activators.

Authors:  Eman M E Dokla; Chun-Sheng Fang; Po-Ting Lai; Samuel K Kulp; Rabah A T Serya; Nasser S M Ismail; Khaled A M Abouzid; Ching-Shih Chen
Journal:  ChemMedChem       Date:  2015-09-09       Impact factor: 3.466

5.  A Novel Phenylchromane Derivative Increases the Rate of Glucose Uptake in L6 Myotubes and Augments Insulin Secretion from Pancreatic Beta-Cells by Activating AMPK.

Authors:  Naomi Rozentul; Yosef Avrahami; Moran Shubely; Laura Levy; Anna Munder; Guy Cohen; Erol Cerasi; Shlomo Sasson; Arie Gruzman
Journal:  Pharm Res       Date:  2017-10-05       Impact factor: 4.200

6.  Hypoglycemic and hypolipidemic effects of a polysaccharide from Lachnum YM240 and its derivatives in mice, induced by a high fat diet and low dose STZ.

Authors:  Yufen Wang; Nana Su; Guohua Hou; Jinglei Li; Ming Ye
Journal:  Medchemcomm       Date:  2017-02-20       Impact factor: 3.597

7.  Identification of Direct Activator of Adenosine Monophosphate-Activated Protein Kinase (AMPK) by Structure-Based Virtual Screening and Molecular Docking Approach.

Authors:  Tonghui Huang; Jie Sun; Shanshan Zhou; Jian Gao; Yi Liu
Journal:  Int J Mol Sci       Date:  2017-06-30       Impact factor: 5.923

8.  Identification of a novel 2-oxindole fluorinated derivative as in vivo antitumor agent for prostate cancer acting via AMPK activation.

Authors:  Alicia Bort; Sergio Quesada; Ágata Ramos-Torres; Marta Gargantilla; Eva María Priego; Sophie Raynal; Franck Lepifre; Jose M Gasalla; Nieves Rodriguez-Henche; Ana Castro; Inés Díaz-Laviada
Journal:  Sci Rep       Date:  2018-03-12       Impact factor: 4.379

9.  AMPK activation by AICAR sensitizes prostate cancer cells to radiotherapy.

Authors:  Colin Rae; Robert J Mairs
Journal:  Oncotarget       Date:  2019-01-22

10.  Hypoglycemic Activity and the Potential Mechanism of the Flavonoid Rich Extract from Sophora tonkinensis Gagnep. in KK-Ay Mice.

Authors:  Mi Huang; Shihao Deng; Qianqian Han; Ping Zhao; Qi Zhou; Sijian Zheng; Xinhua Ma; Chan Xu; Jing Yang; Xinzhou Yang
Journal:  Front Pharmacol       Date:  2016-09-05       Impact factor: 5.810
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.