Literature DB >> 25121743

How a virus blocks a cellular emergency access lane to the nucleus, STAT!

Matthew D Daugherty1, Harmit S Malik2.   

Abstract

Early in viral infection, the STAT1 transcription factor is rapidly transported into the nucleus using a nonconventional import mechanism to establish an antiviral state. In this issue, Xu et al. (2014) show how the Ebola virus VP24 protein precisely blocks specialized STAT1 import while leaving other cellular import processes intact.
Copyright © 2014 Elsevier Inc. All rights reserved.

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Year:  2014        PMID: 25121743     DOI: 10.1016/j.chom.2014.07.013

Source DB:  PubMed          Journal:  Cell Host Microbe        ISSN: 1931-3128            Impact factor:   21.023


  2 in total

1.  Characterizing alpha helical properties of Ebola viral proteins as potential targets for inhibition of alpha-helix mediated protein-protein interactions.

Authors:  Sandeep Chakraborty; Basuthkar J Rao; Bjarni Asgeirsson; Abhaya Dandekar
Journal:  F1000Res       Date:  2014-10-24

2.  STAT3 Regulates the Type I IFN-Mediated Antiviral Response by Interfering with the Nuclear Entry of STAT1.

Authors:  Huanru Wang; Meng Yuan; Shuaibo Wang; Li Zhang; Rui Zhang; Xue Zou; Xiaohui Wang; Deyan Chen; Zhiwei Wu
Journal:  Int J Mol Sci       Date:  2019-09-30       Impact factor: 5.923

  2 in total

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