Literature DB >> 2512138

Decontaminating efficacy of ciprofloxacin in an animal model.

M L van Ogtrop1, H Mattie, H F Guiot, R van Furth.   

Abstract

A study was performed to assess the suppressive effect of ciprofloxacin on the aerobic gram-negative flora of the gastrointestinal tract in mice in relation to its effect on colonization resistance. Ciprofloxacin exhibited a potent decontaminating effect, with the maximum effect being reached at a dose of 8 mg/kg/day. At this dose aerobic gram-negative rods were eliminated from the gastrointestinal tract within 24h without any adverse influence on the parameters of colonization resistance measured.

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Year:  1989        PMID： 2512138     DOI： 10.1007/bf01963780

Source DB:  PubMed          Journal:  Eur J Clin Microbiol Infect Dis        ISSN： 0934-9723            Impact factor:   3.267


  8 in total

1.  The relation between the intestinal microflora and intestinal parameters in mice.

Authors:  J P Koopman; F G Janssen; J A van Druten
Journal:  Z Versuchstierkd       Date:  1977

2.  Changes in the pharmacokinetics of ciprofloxacin and fecal flora during administration of a 7-day course to human volunteers.

Authors:  W Brumfitt; I Franklin; D Grady; J M Hamilton-Miller; A Iliffe
Journal:  Antimicrob Agents Chemother       Date:  1984-11       Impact factor: 5.191

3.  Colonization resistance of the digestive tract: clinical consequences and implications.

Authors:  D van der Waaij
Journal:  J Antimicrob Chemother       Date:  1982-10       Impact factor: 5.790

4.  Ecology of Candida albicans gut colonization: inhibition of Candida adhesion, colonization, and dissemination from the gastrointestinal tract by bacterial antagonism.

Authors:  M J Kennedy; P A Volz
Journal:  Infect Immun       Date:  1985-09       Impact factor: 3.441

5.  Infection management during antileukemia treatment-induced granulocytopenia: the role for oral norfloxacin prophylaxis against infections arising from the gastrointestinal tract.

Authors:  J E Karp; W G Merz; C Hendricksen; B Laughon; T Redden; B J Bamberger; J G Bartlett; R Saral; P J Burke
Journal:  Scand J Infect Dis Suppl       Date:  1986

6.  Quinolones and colonization resistance in human volunteers.

Authors:  J J Van Saene; H K Van Saene; J N Geitz; N J Tarko-Smit; C F Lerk
Journal:  Pharm Weekbl Sci       Date:  1986-02-21

7.  Ciprofloxacin for selective decontamination of the alimentary tract in patients with acute leukemia during remission induction treatment: the effect on fecal flora.

Authors:  M Rozenberg-Arska; A W Dekker; J Verhoef
Journal:  J Infect Dis       Date:  1985-07       Impact factor: 5.226

8.  Effect of oral ciprofloxacin on the faecal flora of healthy volunteers.

Authors:  H A Holt; D A Lewis; L O White; S Y Bastable; D S Reeves
Journal:  Eur J Clin Microbiol       Date:  1986-04       Impact factor: 3.267
  8 in total
  1 in total

1.  Excretion of ciprofloxacin into the large bowel of the rabbit.

Authors:  J Ramon; S Dautrey; R Farinoti; C Carbon; E Rubinstein
Journal:  Antimicrob Agents Chemother       Date:  1996-01       Impact factor: 5.191
  1 in total

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