Alex Fonollosa1, Lorea Martinez-Indart2, Joseba Artaraz1, Agustin Martinez-Berriotxoa3, Koldo Agirrebengoa4, Miriam Garcia4, Leire Lopez-Soria5, Manuel Sorribas6, David Diaz-Valle7, Ricardo Blanco8, Javier Rueda-Gotor8, Alfredo Adan9, Victor Llorenç9, Miguel Cordero-Coma10, Laura Distefano11, Antonio Segura11, Ana Blanco12. 1. a Department of Ophthalmology , BioCruces Health Research Institute, Cruces Hospital, Grupo Oftalmobiología Experimental (GOBE), University of the Basque Country , Bilbao , Spain . 2. b Department of Clinical Epidemiology , BioCruces Health Research Institute, Cruces Hospital, University of the Basque Country , Bilbao , Spain . 3. c Department of Internal Medicine , BioCruces Health Research Institute, Cruces Hospital, University of the Basque Country , Bilbao , Spain . 4. d Department of Infectious Diseases , BioCruces Health Research Institute, Cruces Hospital, University of the Basque Country , Bilbao , Spain . 5. e Department of Microbiology , BioCruces Health Research Institute, Cruces Hospital, University of the Basque Country , Bilbao , Spain . 6. f Department of Ophthalmology , Hospital de Vigo , Spain . 7. g Department of Ophthalmology , Hospital Clinico San Carlos , Madrid , Spain . 8. h Department of Rheumatology , Hospital Marques de Valdecilla , Santander , Spain . 9. i Department of Ophthalmology , Hospital Clinic i Provincial , Barcelona , Spain . 10. j Department of Ophthalmology , Hospital de Leon , Spain . 11. k Department of Ophthalmology Hospital Universitari Vall d'Hebron , Universitat Autonoma de Barcelona , Barcelona , Spain , and. 12. l Department of Ophthalmology , Hospital Donostia , Spain.
Abstract
PURPOSE: To describe the clinical characteristics and to assess visual prognosis of patients with syphilis-associated uveitis in northern Spain. METHODS: Retrospective review of clinical records in eight general uveitis referral centers. RESULTS: Since the year 2000, 50 patients have been diagnosed: 31 men and 19 women; median age was 41 (19-76) years. A total of 34% were co-infected with HIV and 24% presented systemic manifestations of syphilis. Median initial visual acuity and vision at last visit in 93 affected eyes was 20/50 (20/20-20/2000) and 20/22 (20/20-20/2000), respectively (p < .0001). The most frequent manifestation was papillitis (33.3%). Fifty percent of eyes with macular edema on admission presented worsening of visual acuity at last visit, whereas frequency of worsening in eyes without edema was 7.1% (p = 0.009). CONCLUSIONS: In our series, patients with syphilitic uveitis were more usually middle-aged men and were frequently co-infected with HIV. Although most patients showed posterior segment involvement, visual prognosis was good.
PURPOSE: To describe the clinical characteristics and to assess visual prognosis of patients with syphilis-associated uveitis in northern Spain. METHODS: Retrospective review of clinical records in eight general uveitis referral centers. RESULTS: Since the year 2000, 50 patients have been diagnosed: 31 men and 19 women; median age was 41 (19-76) years. A total of 34% were co-infected with HIV and 24% presented systemic manifestations of syphilis. Median initial visual acuity and vision at last visit in 93 affected eyes was 20/50 (20/20-20/2000) and 20/22 (20/20-20/2000), respectively (p < .0001). The most frequent manifestation was papillitis (33.3%). Fifty percent of eyes with macular edema on admission presented worsening of visual acuity at last visit, whereas frequency of worsening in eyes without edema was 7.1% (p = 0.009). CONCLUSIONS: In our series, patients with syphilitic uveitis were more usually middle-aged men and were frequently co-infected with HIV. Although most patients showed posterior segment involvement, visual prognosis was good.
Authors: Elen A Romao; Valdes R Bolella; Maria Estela P Nardin; Maria Lucia Habib-Simao; João Marcelo Furtado; Miguel Moyses-Neto Journal: Rev Inst Med Trop Sao Paulo Date: 2016-05-24 Impact factor: 1.846
Authors: João M Furtado; Tiago E Arantes; Heloisa Nascimento; Daniel V Vasconcelos-Santos; Natalia Nogueira; Rafael de Pinho Queiroz; Luana P Brandão; Thaís Bastos; Ricardo Martinelli; Rodrigo C Santana; Cristina Muccioli; Rubens Belfort; Justine R Smith Journal: Sci Rep Date: 2018-08-13 Impact factor: 4.379