Literature DB >> 25121028

Myofibroblastoma of female breast masquerading as schirrous malignancy - a rare case report with review of literature.

K Bharathi1, Vs Ajay Chandrasekar2, G Hemanathan3, S Anuradha4.   

Abstract

Myofibroblastoma is a rare benign mesenchymal tumour of the breast commonly reported in males. It is a spindle cell neoplasm exhibiting myofibroblastic differentiation with characteristic immunohistochemical staining. Herein, we present a case of myofibroblastoma in a premenopausal female which was mimicking like malignancy clinically. Lump was growing rapidly in size measuring 8 cm x 6 cm and stony hard in consistency. Mammogram showed a large homogeneous hyperdense lump suggestive of fibroadenoma, Hamartoma and fibromatosis. FNAC and trucut biopsy of mass could not be done due to stony hard consistency. Hence excision biopsy was done. Histopathological examination revealed the tumour as myofibroblastoma. Immunohistochemical staining for markers of myofibroblasts like CD-34 and Vimentin showed strong positivity. A negative expression for cytokeratin was noted. This case is presented for its rarity, unusual clinical presentation and stony hard consistency.

Entities:  

Keywords:  Myofibroblastoma Mesenchymal tumours CD 34 Vimentin

Year:  2014        PMID: 25121028      PMCID: PMC4129326          DOI: 10.7860/JCDR/2014/8214.4519

Source DB:  PubMed          Journal:  J Clin Diagn Res        ISSN: 0973-709X


  13 in total

1.  Mammary-type myofibroblastoma of soft tissue: a tumor closely related to spindle cell lipoma.

Authors:  M E McMenamin; C D Fletcher
Journal:  Am J Surg Pathol       Date:  2001-08       Impact factor: 6.394

2.  Myofibroblastoma of the breast. Sixteen cases of a distinctive benign mesenchymal tumor.

Authors:  E S Wargotz; S W Weiss; H J Norris
Journal:  Am J Surg Pathol       Date:  1987-07       Impact factor: 6.394

3.  Cellular angiofibroma: analysis of 25 cases emphasizing its relationship to spindle cell lipoma and mammary-type myofibroblastoma.

Authors:  Uta Flucke; J Han J M van Krieken; Thomas Mentzel
Journal:  Mod Pathol       Date:  2010-09-17       Impact factor: 7.842

4.  Myofibroblastoma of the breast: Case report and literature review.

Authors:  Marco Mele; Vibeke Jensen; Adam Wronecki; Giedrius Lelkaitis
Journal:  Int J Surg Case Rep       Date:  2011-03-03

Review 5.  Rapidly growing myofibroblastoma of the breast diagnosed in a premenopausal woman: management and review of the literature.

Authors:  Nikolaos S Salemis; Georgios Nakos; Evangelos Tsiambas; Vlasios Tsantilas; Charalambos Seretis
Journal:  Breast Dis       Date:  2012

6.  Myofibroblastoma breast with unusual morphological features. Cytohistopathogical diagnostic pitfalls and role of immunohistochemistry-review of literature.

Authors:  B Shivali; Kataria S; K Chandramouleeswari; S Anita
Journal:  J Clin Diagn Res       Date:  2013-10-05

7.  An unusually large myofibroblastoma in a male breast: a case report.

Authors:  Abeywardana Ms Abeysekara; Hp Priyantha Siriwardana; K F Abbas; Peter Tanner; Akin A Ojo
Journal:  J Med Case Rep       Date:  2008-05-14

8.  Giant myofibroblastoma of breast: a case report.

Authors:  Shaila N Shah
Journal:  Indian J Pathol Microbiol       Date:  2007-07       Impact factor: 0.740

9.  Myofibroblastoma of male breast: a case report.

Authors:  Alok Sharma; Achin K Sen; Nishith K Chaturvedi; Rajbala Yadav
Journal:  Indian J Pathol Microbiol       Date:  2007-04       Impact factor: 0.740

10.  Myofibroblastoma of breast.

Authors:  Asim Qureshi; Naila Kayani
Journal:  Indian J Pathol Microbiol       Date:  2008 Jul-Sep       Impact factor: 0.740

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  1 in total

1.  Mammary Myofibroblastoma with Unusual Morphological and Immunohistochemical Features.

Authors:  Ons Boudaouara; Chiraz Chaari; Abdelkhalek Hassini; Tahya Sellami Boudaouara
Journal:  Indian J Med Paediatr Oncol       Date:  2017 Apr-Jun
  1 in total

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