BACKGROUND: A novel gene Caveolin-1(CAV1) was identified to be susceptibility to PR interval and also associated with atrial fibrillation (AF) in two Genome wide associations studies (GWAS) studies in European ancestry. The purpose of this study was to determine the association of the SNPs in CAV1 gene of rs3807989 with AF in Chinese Han patients. METHODS AND RESULTS: We attempted a replication in a cohort of 839 Chinese AF patients and 1215 healthy controls using melting temperature shift allele-specific genotyping analysis. One SNP in CAV1 (rs3807989) was genotyped. The final study cohort consisted of 839 AF patients and 1215 healthy controls. No significant association was detected between rs3807989 and AF in a Chinese Han population (allelic P-adj = 0.828 with OR = 1.02; genotypic P-adj = 0.815, 0.405, 0.760 with a dominant model, recessive model, and additive model). After logistic regression with multiple covariates, the association remained non-significant with adjusted P value 0.828. When the AF cases were further divided into lone AF (31.5%) and other types of AF (68.5%), no significant association was found between rs3807989 and lone AF (P-adj = 0.929 with OR = 0.990) and other types of AF (P-adj = 0.597 with OR = 1.060). CONCLUSION: The SNP rs3807989 in CAV1 gene is not associated with AF or lone AF in our studies, which suggests that the SNP rs3807989 in CAV1 may not be a risk factor for AF in Chinese Han population.
BACKGROUND: A novel gene Caveolin-1(CAV1) was identified to be susceptibility to PR interval and also associated with atrial fibrillation (AF) in two Genome wide associations studies (GWAS) studies in European ancestry. The purpose of this study was to determine the association of the SNPs in CAV1 gene of rs3807989 with AF in Chinese Han patients. METHODS AND RESULTS: We attempted a replication in a cohort of 839 Chinese AFpatients and 1215 healthy controls using melting temperature shift allele-specific genotyping analysis. One SNP in CAV1 (rs3807989) was genotyped. The final study cohort consisted of 839 AFpatients and 1215 healthy controls. No significant association was detected between rs3807989 and AF in a Chinese Han population (allelic P-adj = 0.828 with OR = 1.02; genotypic P-adj = 0.815, 0.405, 0.760 with a dominant model, recessive model, and additive model). After logistic regression with multiple covariates, the association remained non-significant with adjusted P value 0.828. When the AF cases were further divided into lone AF (31.5%) and other types of AF (68.5%), no significant association was found between rs3807989 and lone AF (P-adj = 0.929 with OR = 0.990) and other types of AF (P-adj = 0.597 with OR = 1.060). CONCLUSION: The SNP rs3807989 in CAV1 gene is not associated with AF or lone AF in our studies, which suggests that the SNP rs3807989 in CAV1 may not be a risk factor for AF in Chinese Han population.
Authors: B Razani; J A Engelman; X B Wang; W Schubert; X L Zhang; C B Marks; F Macaluso; R G Russell; M Li; R G Pestell; D Di Vizio; H Hou; B Kneitz; G Lagaud; G J Christ; W Edelmann; M P Lisanti Journal: J Biol Chem Date: 2001-07-16 Impact factor: 5.157
Authors: Morten S Olesen; Anders G Holst; Javad Jabbari; Jonas B Nielsen; Ingrid E Christophersen; Ahmad Sajadieh; Stig Haunsø; Jesper H Svendsen Journal: Can J Cardiol Date: 2012-02-14 Impact factor: 5.223
Authors: You-Yang Zhao; Yang Liu; Radu-Virgil Stan; Lian Fan; Yusu Gu; Nancy Dalton; Po-Hsien Chu; Kirk Peterson; John Ross; Kenneth R Chien Journal: Proc Natl Acad Sci U S A Date: 2002-08-12 Impact factor: 11.205
Authors: Anne M Butler; Xiaoyan Yin; Daniel S Evans; Michael A Nalls; Erin N Smith; Toshiko Tanaka; Guo Li; Sarah G Buxbaum; Eric A Whitsel; Alvaro Alonso; Dan E Arking; Emelia J Benjamin; Gerald S Berenson; Josh C Bis; Wei Chen; Rajat Deo; Patrick T Ellinor; Susan R Heckbert; Gerardo Heiss; Wen-Chi Hsueh; Brendan J Keating; Kathleen F Kerr; Yun Li; Marian C Limacher; Yongmei Liu; Steven A Lubitz; Kristin D Marciante; Reena Mehra; Yan A Meng; Anne B Newman; Christopher Newton-Cheh; Kari E North; Cameron D Palmer; Bruce M Psaty; P Miguel Quibrera; Susan Redline; Alex P Reiner; Jerome I Rotter; Renate B Schnabel; Nicholas J Schork; Andrew B Singleton; J Gustav Smith; Elsayed Z Soliman; Sathanur R Srinivasan; Zhu-ming Zhang; Alan B Zonderman; Luigi Ferrucci; Sarah S Murray; Michele K Evans; Nona Sotoodehnia; Jared W Magnani; Christy L Avery Journal: Circ Cardiovasc Genet Date: 2012-11-08