Literature DB >> 2511991

Cholera and pertussis toxins amplify prostacyclin synthesis in aortic smooth muscle cells.

D Demolle1, J M Boeynaems.   

Abstract

Pretreatment of bovine aortic smooth muscle cells in culture with pertussis toxin (PT) or cholera toxin (CT) potentiated the synthesis of prostacyclin (PGI2) induced by 5-hydroxytryptamine (5-HT) and phorbol-12-myristate, 13-acetate (PMA). The production of PGI2 by explants from the bovine aortic media was also synergistically stimulated by 5-HT and CT, whereas PT was inactive. These data are consistent with the hypothesis that guanosine 5'-triphosphate binding proteins are directly involved in the control of phospholipases which release free arachidonic acid for prostaglandin synthesis.

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Year:  1989        PMID： 2511991      PMCID： PMC1854769          DOI： 10.1111/j.1476-5381.1989.tb14597.x

Source DB:  PubMed          Journal:  Br J Pharmacol        ISSN： 0007-1188            Impact factor:   8.739


  15 in total

1.  Stimulation of aortic smooth muscle prostacyclin by serotonin: role of distinct receptors in contractile and synthetic states.

Authors:  D Demolle; A Van Coevorden; J M Boeynaems
Journal:  Circ Res       Date:  1989-04       Impact factor: 17.367

2.  Stimulation of prostacyclin release from aortic smooth muscle cells by purine and pyrimidine nucleotides.

Authors:  D Demolle; C Lagneau; J M Boeynaems
Journal:  Eur J Pharmacol       Date:  1988-10-18       Impact factor: 4.432

3.  Role of protein kinase C in the control of vascular prostacyclin: study of phorbol esters effect in bovine aortic endothelium and smooth muscle.

Authors:  D Demolle; J M Boeynaems
Journal:  Prostaglandins       Date:  1988-02

4.  Identification of a serotonin type 2 receptor linked to prostacyclin synthesis in vascular smooth muscle cells.

Authors:  S R Coughlin; M A Moskowitz; L Levine
Journal:  Biochem Pharmacol       Date:  1984-02-15       Impact factor: 5.858

5.  Dual role of GTP-binding proteins in the control of endothelial prostacyclin.

Authors:  S Pirotton; C Erneux; J M Boeynaems
Journal:  Biochem Biophys Res Commun       Date:  1987-09-30       Impact factor: 3.575

6.  Alpha 1-adrenergic receptor-mediated phosphoinositide hydrolysis and prostaglandin E2 formation in Madin-Darby canine kidney cells. Possible parallel activation of phospholipase C and phospholipase A2.

Authors:  S R Slivka; P A Insel
Journal:  J Biol Chem       Date:  1987-03-25       Impact factor: 5.157

7.  5-HT2 receptor-stimulated inositol phosphate formation in rat aortic myocytes.

Authors:  R N Cory; P Berta; J Haiech; J Bockaert
Journal:  Eur J Pharmacol       Date:  1986-11-12       Impact factor: 4.432

8.  Cholera toxin and pertussis toxin stimulate prostaglandin E2 synthesis in a murine macrophage cell line.

Authors:  R M Burch; C Jelsema; J Axelrod
Journal:  J Pharmacol Exp Ther       Date:  1988-02       Impact factor: 4.030

9.  The smooth muscle cell. II. Growth of smooth muscle in culture and formation of elastic fibers.

Authors:  R Ross
Journal:  J Cell Biol       Date:  1971-07       Impact factor: 10.539

10.  Phenotype-dependent response of cultured aortic smooth muscle to serum mitogens.

Authors:  J H Chamley-Campbell; G R Campbell; R Ross
Journal:  J Cell Biol       Date:  1981-05       Impact factor: 10.539
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  9 in total

1.  Proceedings of the British Pharmacological Society Meeting. 3rd-5th January 1990. Abstracts.

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Journal:  Br J Pharmacol       Date:  1990-04       Impact factor: 8.739

2.  Proceedings of the British Pharmacological Society Meeting. Sheffield, 18-20th April 1990.

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Journal:  Br J Pharmacol       Date:  1990-06       Impact factor: 8.739

3.  Inhibition of Ca(2+)-sensitive K+ currents in NG 108-15 cells by substance P and related tachykinins.

Authors:  S Phenna; E Carpenter; C Peers; S Maudsley; J P Gent
Journal:  Br J Pharmacol       Date:  1996-09       Impact factor: 8.739

4.  Novel selective agonists and antagonists confirm neurokinin NK1 receptors in guinea-pig vas deferens.

Authors:  J M Hall; I K Morton
Journal:  Br J Pharmacol       Date:  1991-02       Impact factor: 8.739

5.  Endogenous tachykinins facilitate transmission through parasympathetic ganglia in guinea-pig trachea.

Authors:  N Watson; J Maclagan; P J Barnes
Journal:  Br J Pharmacol       Date:  1993-07       Impact factor: 8.739

6.  Characterization of histamine-H3 receptors controlling non-adrenergic non-cholinergic contractions of the guinea-pig isolated ileum.

Authors:  S J Taylor; G J Kilpatrick
Journal:  Br J Pharmacol       Date:  1992-03       Impact factor: 8.739

7.  Characterization of the receptor mediating relaxation to substance P in canine middle cerebral artery: no evidence for involvement of substance P in neurogenically mediated relaxation.

Authors:  C M Stubbs; G J Waldron; H E Connor; W Feniuk
Journal:  Br J Pharmacol       Date:  1992-04       Impact factor: 8.739

8.  Receptors mediating tachykinin-induced contractile responses in guinea-pig trachea.

Authors:  S J Ireland; F Bailey; A Cook; R M Hagan; C C Jordan; M L Stephens-Smith
Journal:  Br J Pharmacol       Date:  1991-06       Impact factor: 8.739

9.  A pharmacological study of NK1 and NK2 tachykinin receptor characteristics in the rat isolated urinary bladder.

Authors:  J M Hall; J M Flowers; I K Morton
Journal:  Br J Pharmacol       Date:  1992-11       Impact factor: 8.739
  9 in total

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