OBJECTIVES:Spinal cord stimulation (SCS) is increasingly used to treat various chronic pain conditions. One undetermined issue is to what extent SCS alters the processing of sensory information from the periphery, including those stimuli that are mediated by small-fiber populations. We aimed to investigate these possible changes using quantitative sensory testing (QST). METHODS:Fourteen patients in long-term SCS treatment for complex regional pain syndrome (n=5) or pain following peripheral nerve injury (n=9) were examined with QST. All patients answered questions about their pain and underwent QST while the SCS treatment was activated and deactivated (12 h interval between the sessions) in a randomized, double-blinded crossover setting. Both the painful side and the corresponding contralateral side were examined. RESULTS: Thermal and mechanical thresholds were similar during SCS activation and deactivation. The same result was found for intensity of pain and areas with painful symptoms even though all patients had documented long-term benefit of the treatment. DISCUSSION: The results support existing evidence suggesting that SCS does not change sensory characteristics, which is important information for both patients and clinicians. Changes in pain intensity after deactivation of SCS may be different in short-term and long-term SCS treatment.
RCT Entities:
OBJECTIVES: Spinal cord stimulation (SCS) is increasingly used to treat various chronic pain conditions. One undetermined issue is to what extent SCS alters the processing of sensory information from the periphery, including those stimuli that are mediated by small-fiber populations. We aimed to investigate these possible changes using quantitative sensory testing (QST). METHODS: Fourteen patients in long-term SCS treatment for complex regional pain syndrome (n=5) or pain following peripheral nerve injury (n=9) were examined with QST. All patients answered questions about their pain and underwent QST while the SCS treatment was activated and deactivated (12 h interval between the sessions) in a randomized, double-blinded crossover setting. Both the painful side and the corresponding contralateral side were examined. RESULTS: Thermal and mechanical thresholds were similar during SCS activation and deactivation. The same result was found for intensity of pain and areas with painful symptoms even though all patients had documented long-term benefit of the treatment. DISCUSSION: The results support existing evidence suggesting that SCS does not change sensory characteristics, which is important information for both patients and clinicians. Changes in pain intensity after deactivation of SCS may be different in short-term and long-term SCS treatment.
Authors: Jacob Caylor; Rajiv Reddy; Sopyda Yin; Christina Cui; Mingxiong Huang; Charles Huang; Rao Ramesh; Dewleen G Baker; Alan Simmons; Dmitri Souza; Samer Narouze; Ricardo Vallejo; Imanuel Lerman Journal: Bioelectron Med Date: 2019-06-28
Authors: Neil E O'Connell; Michael C Ferraro; William Gibson; Andrew Sc Rice; Lene Vase; Doug Coyle; Christopher Eccleston Journal: Cochrane Database Syst Rev Date: 2021-12-02
Authors: Thomas Kinfe; Nico von Willebrand; Andreas Stadlbauer; Michael Buchfelder; Thomas L Yearwood; Sajjad Muhammad; Shafqat R Chaudhry; Sascha Gravius; Thomas Randau; Klemens Winder; Christian Maihöfner; Nadine Gravius; Walter Magerl Journal: J Transl Med Date: 2020-10-21 Impact factor: 5.531