BACKGROUND: The assisted reproductive techniques aimed to assist infertile couples have their own offspring carry significant risks of passing on molecular defects to next generations. RESULTS: Novel breakthroughs in gene and protein interactions have been achieved in the field of male infertility using genome-wide proteomics and transcriptomics technologies. CONCLUSION: Male Infertility is a complex and multifactorial disorder. SIGNIFICANCE: This review provides a comprehensive, up-to-date evaluation of the multifactorial factors involved in male infertility. These factors need to be first assessed and understood before we can successfully treat male infertility.
BACKGROUND: The assisted reproductive techniques aimed to assist infertile couples have their own offspring carry significant risks of passing on molecular defects to next generations. RESULTS: Novel breakthroughs in gene and protein interactions have been achieved in the field of male infertility using genome-wide proteomics and transcriptomics technologies. CONCLUSION:Male Infertility is a complex and multifactorial disorder. SIGNIFICANCE: This review provides a comprehensive, up-to-date evaluation of the multifactorial factors involved in male infertility. These factors need to be first assessed and understood before we can successfully treat male infertility.
Authors: Vincenzo Rochira; Antonio R M Granata; Bruno Madeo; Lucia Zirilli; Giuseppina Rossi; Cesare Carani Journal: Asian J Androl Date: 2005-03 Impact factor: 3.285
Authors: Monis Bilal Shamsi; Rakesh Kumar; Audesh Bhatt; R N K Bamezai; Rajeev Kumar; Narmada P Gupta; T K Das; Rima Dada Journal: Indian J Urol Date: 2008-04
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