Literature DB >> 25117110

Vitamin K deficiency bleeding leading to the diagnosis of Crohn's disease.

Luisa Agnello1, Chiara Bellia1, Lucio Lo Coco2, Silvana Vitale2, Felicia Coraci2, Filippa Bonura2, Rossella Gnoffo2, Mariasanta Napolitano3, Antonietta Caruso1, Giulia Bivona1, Bruna Lo Sasso1, Marcello Ciaccio4.   

Abstract

We report the case of a 45 year old man who came to Emergency Room of Polyclinic for sudden onset of localized ecchymosis and widespread hematomas. He was subjected to blood count and first level investigations to assess coagulation. Based on the results, second level investigations were performed. Endoscopy of the gastrointestinal tract with histological examination revealed a diagnosis of Crohn's disease. Vitamin K deficiency causes the formation of vitamin K-dependent clotting factors that cannot perform their pro-coagulant action. Consequently, patients present with hemorrhagic manifestations. Clinical and laboratory features observed in this patient show that the deficiency of vitamin K-dependent coagulation factors may reveal a complex clinical condition such as an inflammatory bowel disease.
© 2014 by the Association of Clinical Scientists, Inc.

Entities:  

Keywords:  Crohn’s disease; Vitamin K; thromboelastogram

Mesh:

Year:  2014        PMID: 25117110

Source DB:  PubMed          Journal:  Ann Clin Lab Sci        ISSN: 0091-7370            Impact factor:   1.256


  3 in total

Review 1.  Practical clinical approach to the evaluation of hepatobiliary disorders in inflammatory bowel disease.

Authors:  Afif Yaccob; Amir Mari
Journal:  Frontline Gastroenterol       Date:  2018-10-09

2.  Impaired Coagulation Status in the Crohn's Disease Patients Complicated with Intestinal Fistula.

Authors:  Yuan Li; Jian-An Ren; Ge-Fei Wang; Guo-Sheng Gu; Xiu-Wen Wu; Song Liu; Hua-Jian Ren; Zhi-Wu Hong; Jie-Shou Li
Journal:  Chin Med J (Engl)       Date:  2018-03-05       Impact factor: 2.628

3.  Linking Inflammatory Bowel Disease Symptoms to Changes in the Gut Microbiome Structure and Function.

Authors:  Sayf Al-Deen Hassouneh; Mark Loftus; Shibu Yooseph
Journal:  Front Microbiol       Date:  2021-07-19       Impact factor: 5.640

  3 in total

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