Literature DB >> 25116889

Mechanistic studies of Gd3+-based MRI contrast agents for Zn2+ detection: towards rational design.

Célia S Bonnet1, Fabien Caillé, Agnès Pallier, Jean-François Morfin, Stéphane Petoud, Franck Suzenet, Éva Tóth.   

Abstract

A series of novel pyridine-based Gd(3+) complexes have been prepared and studied as potential MRI contrast agents for Zn(2+) detection. By independent assessment of molecular parameters affecting relaxivity, we could interpret the relaxivity changes observed upon Zn(2+) binding in terms of variations of the rotational motion.
© 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Entities:  

Keywords:  NMR spectroscopy; lanthanides; relaxation; sensors; zinc

Mesh：

Substances：

Year:  2014        PMID： 25116889     DOI： 10.1002/chem.201403043

Source DB:  PubMed          Journal:  Chemistry        ISSN： 0947-6539            Impact factor:   5.236


  4 in total

1.  Amplifying the sensitivity of zinc(II) responsive MRI contrast agents by altering water exchange rates.

Authors:  Jing Yu; André F Martins; Christian Preihs; Veronica Clavijo Jordan; Sara Chirayil; Piyu Zhao; Yunkou Wu; Khaled Nasr; Garry E Kiefer; A Dean Sherry
Journal:  J Am Chem Soc       Date:  2015-10-29       Impact factor: 15.419

2.  Imaging Insulin Secretion from Mouse Pancreas by MRI Is Improved by Use of a Zinc-Responsive MRI Sensor with Lower Affinity for Zn2+ Ions.

Authors:  André F Martins; Veronica Clavijo Jordan; Filip Bochner; Sara Chirayil; Namini Paranawithana; Shanrong Zhang; Su-Tang Lo; Xiaodong Wen; Piyu Zhao; Michal Neeman; A Dean Sherry
Journal:  J Am Chem Soc       Date:  2018-12-11       Impact factor: 15.419

3.  Manganese(II)-Based Responsive Contrast Agent Detects Glucose-Stimulated Zinc Secretion from the Mouse Pancreas and Prostate by MRI.

Authors:  Sara Chirayil; Veronica Clavijo Jordan; André F Martins; Namini Paranawithana; S James Ratnakar; A Dean Sherry
Journal:  Inorg Chem       Date:  2021-01-28       Impact factor: 5.165

4.  Fast Ion-Chelate Dissociation Rate for In Vivo MRI of Labile Zinc with Frequency-Specific Encodability.

Authors:  Nishanth D Tirukoti; Liat Avram; Talia Haris; Benjamin Lerner; Yael Diskin-Posner; Hyla Allouche-Arnon; Amnon Bar-Shir
Journal:  J Am Chem Soc       Date:  2021-07-23       Impact factor: 15.419
  4 in total

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