BACKGROUND: The karyotype is a predictor of outcomes in adults with acute lymphoblastic leukemia (ALL). The unfavorable prognostic significance of complex karyotype (CK) has been reported, whereas the prognostic relevance of monosomal karyotype (MK) has not been consistently evaluated. We aimed to assess the prognostic value of CK and MK in adults with ALL treated with risk-adapted protocols of the Spanish PETHEMA Group. METHODS: The karyotypes of 881 adult ALL patients treated according to the protocols of the PETHEMA Group between 1993 and 2012 were centrally reviewed. CK and MK were assessed according to Moorman's criteria, and Breem's criteria, respectively. Specific analyses according to the risk groups and to the presence of t(9:22) were performed. RESULTS: Of 364 evaluable patients 33 (9.2%) had CK, and 68 of 535 evaluable patients (12.8%) had MK. Complete remission rate, remission duration, and overall survival were not significantly different according to the presence of CK or MK in the whole series, according to the B or T lineage, in the high-risk group, or in patients with t(9;22), regardless of imatinib treatment, and in patients who received chemotherapy alone or chemotherapy followed by stem cell transplantation CONCLUSIONS: Our study shows that CK and MK were not associated with a worse prognosis in adult patients with ALL treated with risk-adapted or subtype-oriented protocols. In patients with Ph+ ALL, MK did not have an impact on prognosis irrespective of imatinib treatment.
BACKGROUND: The karyotype is a predictor of outcomes in adults with acute lymphoblastic leukemia (ALL). The unfavorable prognostic significance of complex karyotype (CK) has been reported, whereas the prognostic relevance of monosomal karyotype (MK) has not been consistently evaluated. We aimed to assess the prognostic value of CK and MK in adults with ALL treated with risk-adapted protocols of the Spanish PETHEMA Group. METHODS: The karyotypes of 881 adult ALL patients treated according to the protocols of the PETHEMA Group between 1993 and 2012 were centrally reviewed. CK and MK were assessed according to Moorman's criteria, and Breem's criteria, respectively. Specific analyses according to the risk groups and to the presence of t(9:22) were performed. RESULTS: Of 364 evaluable patients 33 (9.2%) had CK, and 68 of 535 evaluable patients (12.8%) had MK. Complete remission rate, remission duration, and overall survival were not significantly different according to the presence of CK or MK in the whole series, according to the B or T lineage, in the high-risk group, or in patients with t(9;22), regardless of imatinib treatment, and in patients who received chemotherapy alone or chemotherapy followed by stem cell transplantation CONCLUSIONS: Our study shows that CK and MK were not associated with a worse prognosis in adult patients with ALL treated with risk-adapted or subtype-oriented protocols. In patients with Ph+ ALL, MK did not have an impact on prognosis irrespective of imatinib treatment.
Authors: Aleksandr Lazaryan; Michelle Dolan; Mei-Jie Zhang; Hai-Lin Wang; Mohamed A Kharfan-Dabaja; David I Marks; Nelli Bejanyan; Edward Copelan; Navneet S Majhail; Edmund K Waller; Nelson Chao; Tim Prestidge; Taiga Nishihori; Partow Kebriaei; Yoshihiro Inamoto; Betty Hamilton; Shahrukh K Hashmi; Rammurti T Kamble; Ulrike Bacher; Gerhard C Hildebrandt; Patrick J Stiff; Joseph McGuirk; Ibrahim Aldoss; Amer M Beitinjaneh; Lori Muffly; Ravi Vij; Richard F Olsson; Michael Byrne; Kirk R Schultz; Mahmoud Aljurf; Matthew Seftel; Mary Lynn Savoie; Bipin N Savani; Leo F Verdonck; Mitchell S Cairo; Nasheed Hossain; Vijaya Raj Bhatt; Haydar A Frangoul; Hisham Abdel-Azim; Monzr Al Malki; Reinhold Munker; David Rizzieri; Nandita Khera; Ryotaro Nakamura; Olle Ringdén; Marjolein van der Poel; Hemant S Murthy; Hongtao Liu; Shahram Mori; Satiro De Oliveira; Javier Bolaños-Meade; Mahmoud Elsawy; Pere Barba; Sunita Nathan; Biju George; Attaphol Pawarode; Michael Grunwald; Vaibhav Agrawal; Youjin Wang; Amer Assal; Paul Castillo Caro; Yachiyo Kuwatsuka; Sachiko Seo; Celalettin Ustun; Ioannis Politikos; Hillard M Lazarus; Wael Saber; Brenda M Sandmaier; Marcos De Lima; Mark Litzow; Veronika Bachanova; Daniel Weisdorf Journal: Haematologica Date: 2019-09-26 Impact factor: 9.941