Literature DB >> 2511629

A nondeletional mechanism of thymic self tolerance.

F Ramsdell1, T Lantz, B J Fowlkes.   

Abstract

T cells become tolerant of self antigens during their development in the thymus. Clonal deletion of thymocytes bearing self-reactive T cell receptors is a major mechanism for generating tolerance and occurs readily for antigens expressed by bone marrow-derived cells. Tolerance to antigens expressed on the radioresistant thymic stromal elements is demonstrated here to occur via a nondeletional mechanism. For minor lymphocyte stimulatory (Mls-1a) and major histocompatibility complex (MHC) antigens, this alternate form of tolerance induction results in clonal anergy.

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Year:  1989        PMID： 2511629     DOI： 10.1126/science.2511629

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  73 in total

1.  In vivo maintenance of T-lymphocyte unresponsiveness induced by thymic medullary epithelium requires antigen presentation by radioresistant cells.

Authors:  Denis Hudrisier; Sonia Feau; Véronique Bonnet; Paola Romagnoli; Joost P M Van Meerwijk
Journal:  Immunology       Date:  2003-01       Impact factor: 7.397

Review 2.  T cells causing immunological disease.

Authors:  R M Zinkernagel; H Pircher; P S Ohashi; H Hengartner
Journal:  Springer Semin Immunopathol       Date:  1992

Review 3.  Mechanisms of self-nonself discrimination and possible clinical relevance.

Authors:  Carolin Daniel; Jens Nolting; Harald von Boehmer
Journal:  Immunotherapy       Date:  2009-07       Impact factor: 4.196

4.  Thymus: a direct target tissue in graft-versus-host reaction after allogeneic bone marrow transplantation that results in abrogation of induction of self-tolerance.

Authors:  N Fukushi; H Arase; B Wang; K Ogasawara; T Gotohda; R A Good; K Onoé
Journal:  Proc Natl Acad Sci U S A       Date:  1990-08       Impact factor: 11.205

5.  Thymic stromal lymphopoietin-activated plasmacytoid dendritic cells induce the generation of FOXP3+ regulatory T cells in human thymus.

Authors:  Shino Hanabuchi; Tomoki Ito; Woon-Ryon Park; Norihiko Watanabe; Joanne L Shaw; Eulogia Roman; Kazuhiko Arima; Yui-Hsi Wang; Kui Shin Voo; Wei Cao; Yong-Jun Liu
Journal:  J Immunol       Date:  2010-02-19       Impact factor: 5.422

6.  Molecular signature of recent thymic selection events on effector and regulatory CD4+ T lymphocytes.

Authors:  Paola Romagnoli; Denis Hudrisier; Joost P M van Meerwijk
Journal:  J Immunol       Date:  2005-11-01       Impact factor: 5.422

7.  Agonist ligands expressed by thymic epithelium enhance positive selection of regulatory T lymphocytes from precursors with a normally diverse TCR repertoire.

Authors:  Julie Ribot; Paola Romagnoli; Joost P M van Meerwijk
Journal:  J Immunol       Date:  2006-07-15       Impact factor: 5.422

Review 8.  TSLP in epithelial cell and dendritic cell cross talk.

Authors:  Yong-Jun Liu
Journal:  Adv Immunol       Date:  2009       Impact factor: 3.543

9.  Shaping of the autoreactive regulatory T cell repertoire by thymic cortical positive selection.

Authors:  Julie Ribot; Geneviève Enault; Sylvie Pilipenko; Anne Huchenq; Maryline Calise; Denis Hudrisier; Paola Romagnoli; Joost P M van Meerwijk
Journal:  J Immunol       Date:  2007-11-15       Impact factor: 5.422

10.  Breakdown of self-tolerance by intrathymic injection of a T-cell line inducing autoimmune gastritis in mice.

Authors:  A Nishio; T Katakai; M Hosono; M Inaba; M Sakai; M Okuma; S Kasakura; T Masuda
Journal:  Immunology       Date:  1995-06       Impact factor: 7.397
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