| Literature DB >> 25116185 |
Enrica Gianotti1, Bianca Martins Estevão, Fabio Cucinotta, Noboru Hioka, Manuela Rizzi, Filippo Renò, Leonardo Marchese.
Abstract
Organically modified mesoporous silica nanoparticles (MSNs) containing rose bengal (RB), a xanthene dye, were successfully synthesized. RB-modified MSNs have shown a relevant photostability and a high efficiency in the photoproduction and delivery of singlet oxygen ((1)O2), which is particularly promising for photodynamic therapy (PDT) applications. In vitro tests have evidenced that RB-MSNs are able to reduce cell proliferation in one of the most aggressive skin cancer types (SK-MEL-28) after green-light irradiation.Entities:
Keywords: Rose Bengal; cytotoxicity; mesoporous silica nanoparticles; photodynamic therapy; singlet oxygen
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Year: 2014 PMID: 25116185 DOI: 10.1002/chem.201404296
Source DB: PubMed Journal: Chemistry ISSN: 0947-6539 Impact factor: 5.236