[The function of the hypophyseo-gonadal system in hamadryas baboons during the tonic infusion of a luliberin agonist--buserelin].

The authors presented the results of a study of hormonal function of the hypophyseal-gonadal system in Papio hamadryas males subjected to continuous infusion of buzereline (LH-RH agonist) at a daily dose of 3 micrograms/kg of body mass for 4-6 weeks with the help of subcutaneously implanted osmotic mini-pumps. A two-phasic response of the system to the drug was established. Activation of the secretion of hypophyseal gonadotrophins and testicular androgens in the first days of buzereline infusion was followed by sharp inhibition of endocrine function of the hypophyseal-gonadal system. Functional tests with the administration of LH-RH (100 micrograms) and human chorionic gonadotrophin (1500 U) to experimental animals demonstrated the leading role of the development of adenohypophyseal desensitization in the mechanism of antifertile drug action.